Editorial: Neuroinflammation in hypoxia and ischaemia
(2022)
Journal Article
Outputs (16)
Astrocyte Activation in Neurovascular Damage and Repair Following Ischaemic Stroke (2021)
Journal Article
Transient or permanent loss of tissue perfusion due to ischaemic stroke can lead to damage to the neurovasculature, and disrupt brain homeostasis, causing long-term motor and cognitive deficits. Despite promising pre-clinical studies, clinically appr... Read More about Astrocyte Activation in Neurovascular Damage and Repair Following Ischaemic Stroke.
characterizing ischaemic tolerance in rat pheochromocytoma (PC12) cells and primary rat neurons (2020)
Journal Article
Preconditioning tissue with sublethal ischaemia or hypoxia can confer tolerance (protection) against subsequent ischaemic challenge. In vitro ischaemic preconditioning (IPC) is typically achieved through oxygen glucose deprivation (OGD), whereas hypo... Read More about characterizing ischaemic tolerance in rat pheochromocytoma (PC12) cells and primary rat neurons.
Post-Ischaemic Immunological Response in the Brain: Targeting Microglia in Ischaemic Stroke Therapy. (2020)
Journal Article
Microglia, the major endogenous immune cells of the central nervous system, mediate critical degenerative and regenerative responses in ischaemic stroke. Microglia become "activated", proliferating, and undergoing changes in morphology, gene and prot... Read More about Post-Ischaemic Immunological Response in the Brain: Targeting Microglia in Ischaemic Stroke Therapy..
Remote manipulation of magnetic nanoparticles using magnetic field gradient to promote cancer cell death (2019)
Journal Article
The manipulation of magnetic nanoparticles (MNPs) using an external magnetic field, has been successfully demonstrated in various biomedical applications. Some have utilised this non-invasive external stimulus and there is an potential to build on th... Read More about Remote manipulation of magnetic nanoparticles using magnetic field gradient to promote cancer cell death.
The Influence of Nicotinamide on Health and Disease in the Central Nervous System (2018)
Journal Article
Nicotinamide, the amide form of vitamin B3 (niacin), has long been associated with neuronal development, survival, and function in the central nervous system (CNS), being implicated in both neuronal death and neuroprotection. Here, we summarise a bod... Read More about The Influence of Nicotinamide on Health and Disease in the Central Nervous System.
Electrophysiological assessment of primary cortical neurons genetically engineered using iron oxide nanoparticles (2017)
Journal Article
The development of safe technologies to genetically modify neurons is of great interest in regenerative neurology, for both translational and basic science applications. Such approaches have conventionally been heavily reliant on viral transduction m... Read More about Electrophysiological assessment of primary cortical neurons genetically engineered using iron oxide nanoparticles.
Using a 3-D multicellular simulation of spinal cord injury with live cell imaging to study the neural immune barrier to nanoparticle uptake (2016)
Journal Article
Development of nanoparticle (NP) based therapies to promote regeneration in sites of central nervous system (CNS; i.e. brain and spinal cord) pathology relies critically on the availability of experimental models that offer biologically valid predict... Read More about Using a 3-D multicellular simulation of spinal cord injury with live cell imaging to study the neural immune barrier to nanoparticle uptake.
Endocytotic potential governs magnetic particle loading in dividing neural cells: studying modes of particle inheritance. (2016)
Journal Article
AIM: To achieve high and sustained magnetic particle loading in a proliferative and endocytotically active neural transplant population (astrocytes) through tailored magnetite content in polymeric iron oxide particles. MATERIALS & METHODS: MPs of var... Read More about Endocytotic potential governs magnetic particle loading in dividing neural cells: studying modes of particle inheritance..