Fibroblast growth factors (FGFs) are polypeptide growth factors and are potent regulators of cell proliferation, cell differentiation, cell migration and angiogenesis (Ornitz and Itoh, 2001). FGFs can bind with fibroblast growth factor receptors with... Read More about Investigating the use of marine-derived glycosaminoglycans as mimetics for heparan sulphate in fibroblast growth factor signalling.
Outputs (169)
The impact on patients of pharmacist-conducted domiciliary COPD annual reviews: a qualitative study (2023)
Thesis
Introduction Globally, Chronic Obstructive Pulmonary Disease (COPD) is one of the most important non-communicable diseases with a progressive downhill course.1 Guidelines recommend regular review of patients with COPD.2 In the UK traditionally, ann... Read More about The impact on patients of pharmacist-conducted domiciliary COPD annual reviews: a qualitative study.
Spinal deformity involves a wide spectrum of disease, including congenital, developmental, degenerative and traumatic; affecting infant, adolescence and the elderly. Of these, Sheuermann’s kyphosis is a form of developmental long spinal deformity, ch... Read More about The effect of construct configuration on the mechanical stiffness and strength of spinal implants for kyphotic spinal deformity.
Developing in vitro models of traumatic injury for neural tissue engineering applications (2023)
Thesis
Penetrating traumatic brain injury (pTBI) and spinal cord injury (SCI) cause significant neurological damage and debilitation. The management of these central nervous system (CNS) injuries is largely supportive, with no clinically available regenerat... Read More about Developing in vitro models of traumatic injury for neural tissue engineering applications.
Determining the role of epigenetics in telomerase regulation (2022)
Thesis
Telomeres are guanine-rich 5'-TTAGGG-3' repeats found at the ends of human chromosomes that protect chromosomes from degradation and also provide stabilization. Telomerase macromolecule is the primary enzyme responsible for telomere elongation. Telom... Read More about Determining the role of epigenetics in telomerase regulation.
Remote control healing for osteoarthritis repair (2022)
Thesis
Articular cartilage is a key tissue for the normal functioning of the joints, with a trend for degradation with aging and physical activity. The lack of vascularisation hinders the self-repair, and often a scar tissue replaces the damaged cartilage,... Read More about Remote control healing for osteoarthritis repair.
Factors influencing the commissioning and provision of community pharmacy Emergency Hormonal Contraception services in England (2022)
Thesis
In England, community pharmacies provide services commissioned either nationally or locally. Local commissioning exhibits variation in specification and implementation, exemplified by Emergency Hormonal Contraception (EHC) services. A literature revi... Read More about Factors influencing the commissioning and provision of community pharmacy Emergency Hormonal Contraception services in England.
A multimodal approach to biomarker discovery for spinal cord injury (2022)
Thesis
The extent of the devastating outcomes following spinal cord injury, particularly with respect to neurological function, are difficult to predict. This can make it difficult to plan clinical care and manage patient expectations, both of which can hav... Read More about A multimodal approach to biomarker discovery for spinal cord injury.
Activation of Hypoxia Inducible Factor pathway for neuroprotection in in vitro models of ischaemic stroke (2022)
Thesis
Ischaemic stroke is the most common form of stroke, accounting for appropriate 87% of all strokes. Reperfusion is the only immediate treatment option following ischaemic stroke, however, this option is only applicable to a small percentage of patient... Read More about Activation of Hypoxia Inducible Factor pathway for neuroprotection in in vitro models of ischaemic stroke.
A novel scaffold for cell-based lung tissue engineering (2022)
Thesis
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide and numbers are rising. Tissue engineering approaches have the potential to improve lung function and treat diseases such as COPD. Our aim is to investigate a... Read More about A novel scaffold for cell-based lung tissue engineering.