Outputs (2256)

Synthesis and in vitro Biological Evaluation of Ferrocenyl Side-Chain-Functionalized Paclitaxel Derivatives (2017)
Journal Article
Plażuk, D., Wieczorek, A., Ciszewski, W. M., Kowalczyk, K., Błauż, A., Pawlędzio, S., Makal, A., Eurtivong, C., Arabshahi, H. J., Reynisson, J., Hartinger, C. G., & Rychlik, B. (2017). Synthesis and in vitro Biological Evaluation of Ferrocenyl Side-Chain-Functionalized Paclitaxel Derivatives. ChemMedChem, 12(22), 1882-1892. https://doi.org/10.1002/cmdc.201700576

Taxanes, including paclitaxel, are widely used in cancer therapy. In an attempt to overcome some of the disadvantages entailed with taxane chemotherapy, we devised the synthesis of ferrocenyl-functionalized paclitaxel derivatives and studied their bi... Read More about Synthesis and in vitro Biological Evaluation of Ferrocenyl Side-Chain-Functionalized Paclitaxel Derivatives.

Skin advanced glycation content reflects vaginal tissue glycation level in relation to pregnancy (2017)
Journal Article
Yang. (2017). Skin advanced glycation content reflects vaginal tissue glycation level in relation to pregnancy. Medical Hypotheses, https://doi.org/10.1016/j.mehy.2017.09.016

Abstract A few studies have revealed that the advanced glycation content of the vaginal wall in pelvic organ prolapse tissues is elevated. This elevation makes advanced glycation a significant association with the disease. Early detection of vaginal... Read More about Skin advanced glycation content reflects vaginal tissue glycation level in relation to pregnancy.

Codelivery of anti-cancer agents via double-walled polymeric microparticles/injectable hydrogel: A promising approach for treatment of triple negative breast cancer (2017)
Journal Article
Davoodi, P., Ng, W. C., Srinivasan, M. P., & Wang, C. (2017). Codelivery of anti-cancer agents via double-walled polymeric microparticles/injectable hydrogel: A promising approach for treatment of triple negative breast cancer. Biotechnology and Bioengineering, 114(12), 2931-2946. https://doi.org/10.1002/bit.26406

Triple negative breast cancer (TNBC) is an aggressive sub-type of breast cancer that rarely responds to conventional chemotherapy. Therefore, novel agents or new routes need to be developed to improve treatment efficacy and diminish severe side-effec... Read More about Codelivery of anti-cancer agents via double-walled polymeric microparticles/injectable hydrogel: A promising approach for treatment of triple negative breast cancer.

The Talke of the Towne: News, Crime and the Public Sphere in Seven (2017)
Journal Article
(2017). The Talke of the Towne: News, Crime and the Public Sphere in Seven. Cultural and Social History, https://doi.org/10.1080/14780038.2017.1375703

This article reconsiders ideas of the public sphere in the seventeenth century, by focusing on how public opinion is shaped by the movement o information between media and between receivers. It contends that the scholarly preoccupation with a public... Read More about The Talke of the Towne: News, Crime and the Public Sphere in Seven.

Testosterone replacement therapy: improved sexual desire and erectile function in men with type 2 diabetes following a 30-week randomized placebo-controlled study. (2017)
Journal Article
(2017). Testosterone replacement therapy: improved sexual desire and erectile function in men with type 2 diabetes following a 30-week randomized placebo-controlled study. Andrology, 905 - 913. https://doi.org/10.1111/andr.12399

Although testosterone replacement treatment (TRT) can improve sexual function in many hypogonadal (HG) men with type 2 diabetes (T2DM), some show either no improvement or only in a limited number of domains. Indeed, it is often difficult for the clin... Read More about Testosterone replacement therapy: improved sexual desire and erectile function in men with type 2 diabetes following a 30-week randomized placebo-controlled study..

Iron Biochemistry is Correlated with Amyloid Plaque Morphology in an Established Mouse Model of Alzheimer's Disease. (2017)
Journal Article
Telling, N., Everett, J., Collingwood, J. F., Dobson, J., van der Laan, G., Gallagher, J. J., Wang, J., & Hitchcock, A. P. (2017). Iron Biochemistry is Correlated with Amyloid Plaque Morphology in an Established Mouse Model of Alzheimer's Disease. Cell chemical biology, 24(10), 1205-1215. https://doi.org/10.1016/j.chembiol.2017.07.014

A signature characteristic of Alzheimer's disease (AD) is aggregation of amyloid-beta (Aß) fibrils in the brain. Nevertheless, the links between Aß and AD pathology remain incompletely understood. It has been proposed that neurotoxicity arising from... Read More about Iron Biochemistry is Correlated with Amyloid Plaque Morphology in an Established Mouse Model of Alzheimer's Disease..

Nanoscale correlation of iron biochemistry with amyloid plaque morphology in Alzheimer’s disease transgenic mouse cortex (2017)
Journal Article
Telling, N., Everett, J., Collingwood, J. F., Dobson, J., van der Laan, G., Gallagher, J. J., Wang, J., & Hitchcock, A. P. (2017). Nanoscale correlation of iron biochemistry with amyloid plaque morphology in Alzheimer’s disease transgenic mouse cortex. Cell chemical biology, 24(10), 1205-1215. https://doi.org/10.1016/j.chembiol.2017.07.014

A signature characteristic of Alzheimer's disease (AD) is aggregation of amyloid-beta (Aß) fibrils in the brain. Nevertheless, the links between Aß and AD pathology remain incompletely understood. It has been proposed that neurotoxicity arising from... Read More about Nanoscale correlation of iron biochemistry with amyloid plaque morphology in Alzheimer’s disease transgenic mouse cortex.

OH defects in quartz as monitor for igneous, metamorphic, and sedimentary processes (2017)
Journal Article
(2017). OH defects in quartz as monitor for igneous, metamorphic, and sedimentary processes. American Mineralogist, 1832 -1842. https://doi.org/10.2138/am-2017-6107

Oriented sections of more than 500 quartz grains from sediments, igneous, and metamorphic rocks from different localities in Sweden, Austria, Germany, and South Africa were analyzed by FTIR spectroscopy, and their OH defect content was determined wit... Read More about OH defects in quartz as monitor for igneous, metamorphic, and sedimentary processes.

Artificial Neural Network Analysis of Volatile Organic Compounds for the detection of lung cancer (2017)
Presentation / Conference Contribution
Butcher, J. B., Rutter, A. V., Wootton, A. J., Day, C. R., & Sulé-Suso, J. (2017, September). Artificial Neural Network Analysis of Volatile Organic Compounds for the detection of lung cancer. Presented at 17th Annual UK Workshop on Computational Intelligence, Cardiff, Wales, UK

Lung cancer is a widespread disease and it is well understood that systematic, non-invasive and early detection of this progressive and life-threatening disorder is of vital importance for patient outcomes. In this work we present a convergence of fa... Read More about Artificial Neural Network Analysis of Volatile Organic Compounds for the detection of lung cancer.

Efficacy And Safety Of The Subcutaneous Implantable Cardioverter Defibrillator: A Systematic Review (2017)
Journal Article
Mamas. (2017). Efficacy And Safety Of The Subcutaneous Implantable Cardioverter Defibrillator: A Systematic Review. Heart, 1315-1322. https://doi.org/10.1136/heartjnl-2016-310852

Background:
Subcutaneous implantable cardioverter defibrillators (S-ICD) are an alternative to conventional transvenous implantable cardioverter defibrillators (TV-ICD) in patients not requiring pacing. We sought to define the efficacy and safety of... Read More about Efficacy And Safety Of The Subcutaneous Implantable Cardioverter Defibrillator: A Systematic Review.