Outputs (2253)

Measurement of frailty: development of a primary care framework and validation of an electronic Frailty Index
Thesis
Moody, D. K. Measurement of frailty: development of a primary care framework and validation of an electronic Frailty Index. https://keele-repository.worktribe.com/output/423753

Frailty measurement in primary care and at transitions of care is needed to enable timely identification of frailty, guide interventions and support proactive, integrated care. However, there is currently no single tool for frailty measurement in the... Read More about Measurement of frailty: development of a primary care framework and validation of an electronic Frailty Index.

Optimising canine olfactory ensheathing cell therapy using tissue engineering tools
Thesis
Delaney, A. M. Optimising canine olfactory ensheathing cell therapy using tissue engineering tools. https://keele-repository.worktribe.com/output/423884

The adult mammalian spinal cord is incapable of significant regeneration following injury. As such, spinal injury is a lifelong debilitating condition which represents a significant burden on healthcare globally. Olfactory ensheathing cells (OECs) ha... Read More about Optimising canine olfactory ensheathing cell therapy using tissue engineering tools.

A review of newborn screening results and anthropometric measurements in infants diagnosed with cystic fibrosis in the West Midlands
Thesis
Patterson, K. D. A review of newborn screening results and anthropometric measurements in infants diagnosed with cystic fibrosis in the West Midlands. https://keele-repository.worktribe.com/output/423887

INTRODUCTION:
Newborn screening (NBS) for cystic fibrosis (CF) was implemented nationally in July 2007 and has reduced the age of diagnosis and produced better nutritional and survival outcomes.

AIM:
To assess demographic data of a screened coho... Read More about A review of newborn screening results and anthropometric measurements in infants diagnosed with cystic fibrosis in the West Midlands.

Structural studies of the interaction of bacterial lipopolysaccharides with C-reactive protein and lung surfactant protein D
Thesis
Structural studies of the interaction of bacterial lipopolysaccharides with C-reactive protein and lung surfactant protein D. https://keele-repository.worktribe.com/output/423973

In this thesis, recognition of the complex natural ligand lipopolysaccharide (LPS) by the innate immune proteins C-reactive protein (CRP) from Limulus polyphemus (Atlantic horseshoe crab), and human surfactant protein D, in the form of a recombinant... Read More about Structural studies of the interaction of bacterial lipopolysaccharides with C-reactive protein and lung surfactant protein D.

Novel cartilage repair therapy: The effect of low intensity pulsed ultrasound on chondrocytes
Thesis
Novel cartilage repair therapy: The effect of low intensity pulsed ultrasound on chondrocytes. https://keele-repository.worktribe.com/output/423982

Pathological conditions of cartilage resulting from acute injury are a major cause of morbidity. Surgical intervention, in most cases, does not repair cartilage to its native mechanical resilience. The potential benefits of non-invasive approaches fo... Read More about Novel cartilage repair therapy: The effect of low intensity pulsed ultrasound on chondrocytes.

The influence of the microenvironment on vascularisation of osteochondral tissues
Thesis
The influence of the microenvironment on vascularisation of osteochondral tissues. https://keele-repository.worktribe.com/output/423985

The regulation of vascularisation is a major challenge facing osteochondral tissue engineering. Articular cartilage is an avascular tissue and the presence of blood vessels is associated with various pathologies of the tissue. Conversely, bone requir... Read More about The influence of the microenvironment on vascularisation of osteochondral tissues.

Semi-quantitative immunohistochemical exploration of lung tissue remodelling in idiopathic pulmonary fibrosis
Thesis
Semi-quantitative immunohistochemical exploration of lung tissue remodelling in idiopathic pulmonary fibrosis. https://keele-repository.worktribe.com/output/423987

Aim: This thesis explores the complex cellular and biological interrelationships involved in Idiopathic Pulmonary Fibrosis (IPF) lung tissue remodelling using immunohistochemical analysis. Methods and results: 21 IPF and 19 control lung tissues were... Read More about Semi-quantitative immunohistochemical exploration of lung tissue remodelling in idiopathic pulmonary fibrosis.

Influence of non-steroidal anti-inflammatory drugs on chronic kidney disease progression: an epidemiological study in general practice populations
Thesis
Influence of non-steroidal anti-inflammatory drugs on chronic kidney disease progression: an epidemiological study in general practice populations. https://keele-repository.worktribe.com/output/424000

Chronic kidney disease (CKD) is a major cause of morbidity and mortality worldwide. Identifying and avoiding disease progression risk factors is important in the management of CKD. Non-Steroidal Anti-inflammatory Drugs (NSAIDs), which are commonly pr... Read More about Influence of non-steroidal anti-inflammatory drugs on chronic kidney disease progression: an epidemiological study in general practice populations.

Immunomodulation of the innate response in common carp Cyprinus carpio by ß-glucan feeding and pathogenic infection
Thesis
Immunomodulation of the innate response in common carp Cyprinus carpio by ß-glucan feeding and pathogenic infection. https://keele-repository.worktribe.com/output/424003

Two major components of the common carp Cyprinus carpio innate response, i.e. the C-reactive protein (CRP) and the complement system, have been analysed in common carp either orally immunostimulated with ß-glucan or infected with a pathogen or both.... Read More about Immunomodulation of the innate response in common carp Cyprinus carpio by ß-glucan feeding and pathogenic infection.

The impact of musculoskeletal conditions on outcomes of other illnesses (the MSKCOM study): a linked electronic health record study - Code lists
Data
Marshall, M., Mason, K., Bailey, J., Heron, N., Achanca, F., Chen, Y., Edwards, J., Frisher, M., Huntley, A., Mallen, C., Mamas, M., Png, M., Tatton, S., White, S., & Jordan, K. (2022). The impact of musculoskeletal conditions on outcomes of other illnesses (the MSKCOM study): a linked electronic health record study - Code lists. [Data]

Marshall M, Mason K, Bailey J, Heron N, Achana F, Chen Y, Edwards J, Frisher M, Huntley A, Mallen C, Mamas M, Png ME, Tatton S, White S, Jordan KP. MSKCOM: main Public Output: The impact of musculoskeletal conditions on outcomes of other illnesses: a... Read More about The impact of musculoskeletal conditions on outcomes of other illnesses (the MSKCOM study): a linked electronic health record study - Code lists.