Current orthopaedics treatments of bone defects often involve the use of implanted fixatives and/or autograft procedures to restore function to the afflicted area following injury. Fixatives and implants are usually temporary solutions, since they ar... Read More about The development and validation of a hydrostatic pressure bioreactor for applications in bone tissue engineering.
Outputs (2051)
An evaluation of tailored magnetic nanoparticles in the induction of stem cell differentiation
Thesis
Improving the differentiation capacity of stem cells by defining the ideal physico-chemical and spatial parameters will enhance the efficiency of stem cell-based clinical therapies. In this thesis the hypothesis that heat shock (elevated temperatures... Read More about An evaluation of tailored magnetic nanoparticles in the induction of stem cell differentiation.
Multiple Sclerosis (MS) is one of the commonest disabling neurological diseases affecting the young in the developed world. It affects the central nervous system (CNS) and is characterised by inflammation with neuronal demyelination /degeneration and... Read More about Characterisation of pathogenic T helper and T regulatory cell subsets in relapse and progression in multiple sclerosis.
Anti-inflammatory drugs such as corticosteroids (CSs) and minocycline (MINO) are widely used in the treatment of a range of clinical conditions and to suppress graft rejection in stem cell transplantation therapy. However, such treatment is associate... Read More about An investigation of the mechanisms underpinning the effect of anti-inflammatory drugs on neural stem cells.
Heart failure (HF) disease carries a poor prognosis despite optimisation of cardiovascular (CVD) treatments. Non-CVD comorbid diseases are common and known to influence the HF clinical course. These comorbidities change in severity over time from new... Read More about Time-dependent markers of comorbidity and prognosis in heart failure patients: transitions across the life course.
Iron is vital for healthy brain function. However when present in a redox-active form or in excess concentrations it can be toxic. Interestingly, increased levels of redox-active iron biominerals have been shown to exist in Alzheimer’s disease (AD) t... Read More about The aggregation and reduction of iron minerals by the Alzheimer’s disease peptide ß-amyloid (1-42): an X-ray absorption study.
COPD is a debilitating chronic respiratory disease with a systemic footprint. COPD is a highly heterogeneous disease but invariably its management involves a one-size fits all approach. This fails to address individual variations in disease progressi... Read More about Evaluation of saliva biomarkers in chronic obstructive pulmonary disease: correlation to patient reported outcomes.
Damaged or diseased mature articular cartilage cannot undergo effective tissue repair and due to its avascular, hypocellular nature defects become widespread and painful. No ‘gold standard’ treatment exists for this indication and the ultimate recour... Read More about Investigating the chondrogenic phenotype in clinically relevant cells: the effect of hTERT expression.
The preclinical evaluation of simvastatin and pitavastatin for the treatment of ovarian cancer
Thesis
Ovarian cancer is the fifth most common cancer which affects women in the United Kingdom. The 5-year survival rate is less than 45% despite improvements in chemotherapeutic regimens. Platinum-based therapy in combination with other chemotherapy inclu... Read More about The preclinical evaluation of simvastatin and pitavastatin for the treatment of ovarian cancer.
Engineering Surfaces to Control Neurogenesis
Thesis
Producing therapeutic neural cell populations in vitro to treat neurodegenerative diseases is a key aim of regenerative medicine. Various protocols have been developed to produce a wide range of neural cell types in vitro, but the protocols are labou... Read More about Engineering Surfaces to Control Neurogenesis.