Outputs (2157)

Evaluation of drug combinations to sensitize ovarian cancer cells to chemotherapy
Thesis
(2018). Evaluation of drug combinations to sensitize ovarian cancer cells to chemotherapy

Ovarian cancer is a complex disease characterized by low incidence, accounting for about 4% of cancer diagnoses in women, but with rapid progression and higher mortality rate than any other gynecological malignancy. Approximately 70 % of the cases ar... Read More about Evaluation of drug combinations to sensitize ovarian cancer cells to chemotherapy.

The potential of umbilical cord cells, autologous bone marrow stromal cells and autologous chondrocytes for bone and cartilage repair
Thesis
(2018). The potential of umbilical cord cells, autologous bone marrow stromal cells and autologous chondrocytes for bone and cartilage repair

Aims To evaluate the in vitro potential of umbilical cord(UC)-derived cells as an allogeneic cell source that could be used ‘off-the-shelf’ in orthopaedics for bone and cartilage regeneration. The study also assesses the in-vivo efficacy of cell the... Read More about The potential of umbilical cord cells, autologous bone marrow stromal cells and autologous chondrocytes for bone and cartilage repair.

Electrolytic growth processes with applications to adaptive systems
Thesis
(1963). Electrolytic growth processes with applications to adaptive systems

Two types of electrolytic growth processes have been investigated as possible means of controlling impedances in adaptive systems. One of these entails the growth of conductors by metallic deposition and the other the growth of insulation by anodic o... Read More about Electrolytic growth processes with applications to adaptive systems.

Exploring the impact of hypoxia mimetic agents on multipotent stem cell biology
Thesis
(2018). Exploring the impact of hypoxia mimetic agents on multipotent stem cell biology

Oxygen is an important molecule in life and is essential for a broad spectrum of physiological reactions that include, but are not restricted to, cell metabolism, respiration and growth. Under physiological conditions, oxygen levels vary from one tis... Read More about Exploring the impact of hypoxia mimetic agents on multipotent stem cell biology.

Pro-drug strategies for pancreatic cancer therapy
Thesis
(2018). Pro-drug strategies for pancreatic cancer therapy

Pancreatic cancer is the fourth main cancer in the western world. Currently the only chemotherapy available clinically is gemcitabine. However, gemcitabine treatment only proves effective in 23.8% of patients. Nano-structures (

Towards monitoring of the progress of chemical reactions using a novel plasma-assisted desorption ionisation mass spectrometry methodology
Thesis
(2018). Towards monitoring of the progress of chemical reactions using a novel plasma-assisted desorption ionisation mass spectrometry methodology

A novel method for monitoring of pharmaceutically relevant reactions using PADI-MS has been developed in this study. The visible non-thermal plasma plume from a coaxial helium gas flow non-thermal RF plasma was optimised using a range of samples. PAD... Read More about Towards monitoring of the progress of chemical reactions using a novel plasma-assisted desorption ionisation mass spectrometry methodology.

Investigation into the role of the long non-coding RNAs NEAT1 and MIAT in breast cancer
Thesis
(2018). Investigation into the role of the long non-coding RNAs NEAT1 and MIAT in breast cancer

Several long non-coding RNAs (lncRNAs) have been identified to play key, rate-limiting roles in malignancies, and the mechanisms involved are now being elucidated. This study addressed the roles of NEAT1 and MIAT lncRNAs, in breast cancer. The short... Read More about Investigation into the role of the long non-coding RNAs NEAT1 and MIAT in breast cancer.

Mechanical loading of murine bioengineered skeletal muscle mimics the transcriptional & epigenetic response of human skeletal muscle after exercise
Journal Article
Mechanical loading of murine bioengineered skeletal muscle mimics the transcriptional & epigenetic response of human skeletal muscle after exercise. European cells & materials, 31 - 31

Recent investigations from our lab have characterised the genome-wide epigenetic (DNA methylation) and gene expression changes in skeletal muscle (SkM) following anabolic (resistance) exercise (RE) in humans [1]. We aimed to create 3D bioengineered S... Read More about Mechanical loading of murine bioengineered skeletal muscle mimics the transcriptional & epigenetic response of human skeletal muscle after exercise.

The impact of musculoskeletal conditions on outcomes of other illnesses (the MSKCOM study): a linked electronic health record study - Code lists
Dataset
Marshall, M., Mason, K., Bailey, J., Heron, N., Achanca, F., Chen, Y., …Jordan, K. (2022). The impact of musculoskeletal conditions on outcomes of other illnesses (the MSKCOM study): a linked electronic health record study - Code lists. [Dataset]

Marshall M, Mason K, Bailey J, Heron N, Achana F, Chen Y, Edwards J, Frisher M, Huntley A, Mallen C, Mamas M, Png ME, Tatton S, White S, Jordan KP. MSKCOM: main Public Output: The impact of musculoskeletal conditions on outcomes of other illnesses: a... Read More about The impact of musculoskeletal conditions on outcomes of other illnesses (the MSKCOM study): a linked electronic health record study - Code lists.

Immunomodulation of the innate response in common carp Cyprinus carpio by ß-glucan feeding and pathogenic infection
Thesis
(2013). Immunomodulation of the innate response in common carp Cyprinus carpio by ß-glucan feeding and pathogenic infection

Two major components of the common carp Cyprinus carpio innate response, i.e. the C-reactive protein (CRP) and the complement system, have been analysed in common carp either orally immunostimulated with ß-glucan or infected with a pathogen or both.... Read More about Immunomodulation of the innate response in common carp Cyprinus carpio by ß-glucan feeding and pathogenic infection.