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Outputs (2132)

Optimising canine olfactory ensheathing cell therapy using tissue engineering tools
Thesis
Delaney, A. M. (2016). Optimising canine olfactory ensheathing cell therapy using tissue engineering tools

The adult mammalian spinal cord is incapable of significant regeneration following injury. As such, spinal injury is a lifelong debilitating condition which represents a significant burden on healthcare globally. Olfactory ensheathing cells (OECs) ha... Read More about Optimising canine olfactory ensheathing cell therapy using tissue engineering tools.

A review of newborn screening results and anthropometric measurements in infants diagnosed with cystic fibrosis in the West Midlands
Thesis
Patterson, K. D. (2016). A review of newborn screening results and anthropometric measurements in infants diagnosed with cystic fibrosis in the West Midlands

INTRODUCTION: Newborn screening (NBS) for cystic fibrosis (CF) was implemented nationally in July 2007 and has reduced the age of diagnosis and produced better nutritional and survival outcomes. AIM: To assess demographic data of a screened coho... Read More about A review of newborn screening results and anthropometric measurements in infants diagnosed with cystic fibrosis in the West Midlands.

Changes in advanced glycation content, structural and mechanical properties of vaginal tissue during pregnancy and in prolapse
Thesis
Kinikanwo Weli, H. (2018). Changes in advanced glycation content, structural and mechanical properties of vaginal tissue during pregnancy and in prolapse

Introduction: Pelvic organ prolapse is present in up to 50% of women. It is commoner in older women, often above 50 years of age and associated with hormonal e.g. oestrogen decline, and stiffer vaginal tissue. Pregnancy, on the contrary is a physiolo... Read More about Changes in advanced glycation content, structural and mechanical properties of vaginal tissue during pregnancy and in prolapse.

Pharmacists in general medical practice: a case study of clinical commissioning groups
Thesis
Saunders, R. E. (2018). Pharmacists in general medical practice: a case study of clinical commissioning groups

Pharmacists have been identified to address the increasing workload in United Kingdom (UK) general practice. A pilot has been commissioned by National Health Service England (NHSE) to upskill pharmacists for this purpose. Evaluation is underway and e... Read More about Pharmacists in general medical practice: a case study of clinical commissioning groups.

Silicon in health: A beneficial element in reducing the body burden of aluminium
Thesis
Jones, K. L. (2018). Silicon in health: A beneficial element in reducing the body burden of aluminium

The essentiality of silicon and the toxicity of aluminium within humans are both topics of much debate; the current conception is that silicon is essential in ameliorating aluminium toxicity, however, the evidence for this remains inconclusive. T... Read More about Silicon in health: A beneficial element in reducing the body burden of aluminium.

Cell death in the human malaria parasite: exploring autophagy as a drug target and early cellular events following drug perturbation
Thesis
Ali, I. F. (2018). Cell death in the human malaria parasite: exploring autophagy as a drug target and early cellular events following drug perturbation

The emergence and spread of resistance to antimalarial drugs has highlighted the demand to search for new drugs that target novel pathways in the human malaria parasite Plasmodium falciparum. This thesis explores the potential for targeting of the Pf... Read More about Cell death in the human malaria parasite: exploring autophagy as a drug target and early cellular events following drug perturbation.

Implementation and evaluation of a computerised anticoagulation decision support tool for managing atrial fibrillation
Thesis
Hijazeen, R. (2018). Implementation and evaluation of a computerised anticoagulation decision support tool for managing atrial fibrillation

Background: Anticoagulation therapy for patients with atrial fibrillation (AF) remains a national challenge. A decision support tool (DST) was developed to assist healthcare professionals (HCPs) in the appropriate prescribing of anticoagulants in pat... Read More about Implementation and evaluation of a computerised anticoagulation decision support tool for managing atrial fibrillation.

Clinical simulations using virtual patient avatars for pre-registration pharmacist training: a mixed methods evaluation
Thesis
Thompson, J. (2018). Clinical simulations using virtual patient avatars for pre-registration pharmacist training: a mixed methods evaluation

Virtual patients (VPs) are routinely used in the training of medicine and nursing professionals but uptake into pharmacy has been slower. The pharmacy pre-registration training year takes place in the workplace and a disparity in the perceptions of s... Read More about Clinical simulations using virtual patient avatars for pre-registration pharmacist training: a mixed methods evaluation.

The co-administration of anticancer and pro-apoptotic agents as a novel approach in liver cancer therapy
Thesis
AL-Shakarchi, W. (2018). The co-administration of anticancer and pro-apoptotic agents as a novel approach in liver cancer therapy

Hepatocellular carcinoma accounts for 85% of primary liver cancer that are usually characterised by defective or ineffective apoptosis which is considered to be the main cause of cancer progression. In this study, Cytochrome-C which is a pro-apoptoti... Read More about The co-administration of anticancer and pro-apoptotic agents as a novel approach in liver cancer therapy.