A MIG-15/JNK-1 MAP kinase cascade opposes RPM-1 signaling in synapse formation and learning
(2017)
Journal Article
Crawley, O., Giles, A. C., Desbois, M., Kashyap, S., Birnbaum, R., & Grill, B. (2017). A MIG-15/JNK-1 MAP kinase cascade opposes RPM-1 signaling in synapse formation and learning. PLOS genetics, 13(12), Article e1007095. https://doi.org/10.1371/journal.pgen.1007095
The Pam/Highwire/RPM-1 (PHR) proteins are conserved intracellular signaling hubs that regulate synapse formation and axon termination. The C. elegans PHR protein, called RPM-1, acts as a ubiquitin ligase to inhibit the DLK-1 and MLK-1 MAP kinase path... Read More about A MIG-15/JNK-1 MAP kinase cascade opposes RPM-1 signaling in synapse formation and learning.