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Outputs (6)

The Potential for a Released Autosomal X-Shredder Becoming a Driving-Y Chromosome and Invasively Suppressing Wild Populations of Malaria Mosquitoes (2021)
Journal Article
Alcalay, Y., Fuchs, S., Galizi, R., Bernardini, F., Elaine Haghighat-Khah, R., Rusch, D. B., …Aris Papathanos, P. (2021). The Potential for a Released Autosomal X-Shredder Becoming a Driving-Y Chromosome and Invasively Suppressing Wild Populations of Malaria Mosquitoes. Frontiers in Bioengineering and Biotechnology, https://doi.org/10.3389/fbioe.2021.752253

Sex-ratio distorters based on X-chromosome shredding are more efficient than sterile male releases for population suppression. X-shredding is a form of sex distortion that skews spermatogenesis of XY males towards the preferential transmission of Y-b... Read More about The Potential for a Released Autosomal X-Shredder Becoming a Driving-Y Chromosome and Invasively Suppressing Wild Populations of Malaria Mosquitoes.

A genetically encoded anti-CRISPR protein constrains gene drive spread and prevents population suppression (2021)
Journal Article
Taxiarchi, C., Beaghton, A., Illansinhage Don, N., Kyrou, K., Gribble, M., Shittu, D., …Crisanti, A. (2021). A genetically encoded anti-CRISPR protein constrains gene drive spread and prevents population suppression. Nature communications, 1-8. https://doi.org/10.1038/s41467-021-24214-5

CRISPR-based gene drives offer promising means to reduce the burden of pests and vector-borne diseases. These techniques consist of releasing genetically modified organisms carrying CRISPR-Cas nucleases designed to bias their inheritance and rapidly... Read More about A genetically encoded anti-CRISPR protein constrains gene drive spread and prevents population suppression.

Genetic Technologies for Sustainable Management of Insect Pests and Disease Vectors (2021)
Journal Article
Grilli, S., Galizi, R., & Taxiarchi, C. (2021). Genetic Technologies for Sustainable Management of Insect Pests and Disease Vectors. Sustainability, 5653 - 5653. https://doi.org/10.3390/su13105653

Recent advancements in genetic and genome editing research, augmented by the discovery of new molecular tools such as CRISPR, have revolutionised the field of genetic engineering by enabling precise site-specific genome modifications with unprecedent... Read More about Genetic Technologies for Sustainable Management of Insect Pests and Disease Vectors.

A Code of Ethics for Gene Drive Research. (2021)
Journal Article
Annas, G. J., Beisel, C. L., Clement, K., Crisanti, A., Francis, S., Galardini, M., …Keith Joung, J. (2021). A Code of Ethics for Gene Drive Research. The CRISPR Journal, 19-24. https://doi.org/10.1089/crispr.2020.0096

Gene drives hold promise for use in controlling insect vectors of diseases, agricultural pests, and for conservation of ecosystems against invasive species. At the same time, this technology comes with potential risks that include unknown downstream... Read More about A Code of Ethics for Gene Drive Research..

Regulating the expression of gene drives is key to increasing their invasive potential and the mitigation of resistance (2021)
Journal Article
Hammond, A., Karlsson, X., Morianou, I., Kyrou, K., Beaghton, A., Gribble, M., …Nolan, T. (2021). Regulating the expression of gene drives is key to increasing their invasive potential and the mitigation of resistance. PLoS Genetics, e1009321 - ?. https://doi.org/10.1371/journal.pgen.1009321

Homing-based gene drives use a germline source of nuclease to copy themselves at specific target sites in a genome and bias their inheritance. Such gene drives can be designed to spread and deliberately suppress populations of malaria mosquitoes by i... Read More about Regulating the expression of gene drives is key to increasing their invasive potential and the mitigation of resistance.