Outputs (4)

Changes in NMDA Receptor Function in Rapid Ischemic Tolerance: A Potential Role for Tri-Heteromeric NMDA Receptors (2022)
Journal Article
Xie, M., Leng, T., Maysami, S., Pearson, A., Simon, R., Xiong, Z.-G., & Meller, R. (2022). Changes in NMDA Receptor Function in Rapid Ischemic Tolerance: A Potential Role for Tri-Heteromeric NMDA Receptors. Biomolecules, 12(9), Article 1214. https://doi.org/10.3390/biom12091214

In this study, we characterize biophysical changes in NMDA receptor function in response to brief non-injurious ischemic stress (ischemic preconditioning). Electrophysiological studies show NMDA receptor function is reduced following preconditioning... Read More about Changes in NMDA Receptor Function in Rapid Ischemic Tolerance: A Potential Role for Tri-Heteromeric NMDA Receptors.

A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke (2015)
Journal Article
Wong, R., Pradillo, J. M., Denes, A., Dhungana, H., Malm, T., Koistinaho, J., …Maysami, S. (2015). A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke. Journal of Cerebral Blood Flow and Metabolism, 36(3), 596-605. https://doi.org/10.1177/0271678X15606714

Stroke represents a global challenge and is a leading cause of permanent disability worldwide. Despite much effort, translation of research findings to clinical benefit has not yet been successful. Failure of neuroprotection trials is considered, in... Read More about A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke.

Prolonged diet-induced obesity in mice modifies the inflammatory response and leads to worse outcome after stroke. (2015)
Journal Article
Maysami, S., Haley, M., Gorenkova, N., Krishnan, S., McColl, B., & Lawrence, C. (2015). Prolonged diet-induced obesity in mice modifies the inflammatory response and leads to worse outcome after stroke. Journal of Neuroinflammation, 140 - ?. https://doi.org/10.1186/s12974-015-0359-8

BACKGROUND: Obesity increases the risk for ischaemic stroke and is associated with worse outcome clinically and experimentally. Most experimental studies have used genetic models of obesity. Here, a more clinically relevant model, diet-induced obesit... Read More about Prolonged diet-induced obesity in mice modifies the inflammatory response and leads to worse outcome after stroke..

Neuronal Toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro. (2012)
Journal Article
Maysami, S., Bowie, A., Denes, A., Nilsson, O., Leow-Dyke, S., Allen, C., …Pinteaux, E. (2012). Neuronal Toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro. Journal of Neuroinflammation, 230 - ?. https://doi.org/10.1186/1742-2094-9-230

BACKGROUND: The innate immune response in the brain is initiated by pathogen-associated molecular patterns (PAMPS) or danger-associated molecular patterns (DAMPS) produced in response to central nervous system (CNS) infection or injury. These molecul... Read More about Neuronal Toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro..