Outputs (88)

Carbenoxolone-mediated cytotoxicity inhibits Vaccinia virus replication in a human keratinocyte cell line (2018)
Journal Article
Haga, I. R., Simpson, J. L., Hawes, P. C., & Beard, P. M. (2018). Carbenoxolone-mediated cytotoxicity inhibits Vaccinia virus replication in a human keratinocyte cell line. Scientific Reports, 8, Article 16956. https://doi.org/10.1038/s41598-018-34732-w

The re-emergence of poxviral zoonotic infections and the threat of bioterrorism emphasise the demand
for efective antipoxvirus therapies. Here, we show that carbenoxolone, a pharmacological inhibitor of
gap junction function and a compound widely... Read More about Carbenoxolone-mediated cytotoxicity inhibits Vaccinia virus replication in a human keratinocyte cell line.

The annual, temporal and spatial pattern of Setaria tundra outbreaks in Finnish reindeer: a mechanistic transmission model approach (2018)
Journal Article
Haider, N., Laaksonen, S., Kjær, L. J., Oksanen, A., & Bødker, R. (in press). The annual, temporal and spatial pattern of Setaria tundra outbreaks in Finnish reindeer: a mechanistic transmission model approach. Parasites and Vectors, 11, Article 565. https://doi.org/10.1186/s13071-018-3159-z

Background
In northern Finland (Lapland), reindeer are reared as semi-domesticated animals. The region has a short summer season of 2–3 months, yet reindeer are infected with the mosquito-borne filarioid parasite Setaria tundra. The infection causes... Read More about The annual, temporal and spatial pattern of Setaria tundra outbreaks in Finnish reindeer: a mechanistic transmission model approach.

Unraveling the enigma: elucidating the relationship between the physicochemical properties of aluminium-based adjuvants and their immunological mechanisms of action (2018)
Journal Article
(2018). Unraveling the enigma: elucidating the relationship between the physicochemical properties of aluminium-based adjuvants and their immunological mechanisms of action. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, https://doi.org/10.1186/s13223-018-0305-2

Aluminium salts are by far the most commonly used adjuvants in vaccines. There are only two aluminium salts which are used in clinically-approved vaccines, Alhydrogel® and AdjuPhos®, while the novel aluminium adjuvant used in Gardasil® is a sulphated... Read More about Unraveling the enigma: elucidating the relationship between the physicochemical properties of aluminium-based adjuvants and their immunological mechanisms of action.

RNA virus fidelity mutants: a useful tool for evolutionary biology or a complex challenge? (2018)
Journal Article
(2018). RNA virus fidelity mutants: a useful tool for evolutionary biology or a complex challenge?. Viruses, https://doi.org/10.3390/v10110600

RNA viruses replicate with low fidelity due to the error-prone nature of the RNA-dependent RNA polymerase, which generates approximately one mutation per round of genome replication. Due to the large population sizes produced by RNA viruses during re... Read More about RNA virus fidelity mutants: a useful tool for evolutionary biology or a complex challenge?.

Habitat-specific variation in gut microbial communities and pathogen prevalence in bumblebee queens (Bombus terrestris) (2018)
Journal Article
(2018). Habitat-specific variation in gut microbial communities and pathogen prevalence in bumblebee queens (Bombus terrestris). PloS one, https://doi.org/10.1371/journal.pone.0204612

Gut microbial communities are critical for the health of many insect species. However, little is known about how gut microbial communities respond to anthropogenic changes and how such changes affect host-pathogen interactions. In this study, we used... Read More about Habitat-specific variation in gut microbial communities and pathogen prevalence in bumblebee queens (Bombus terrestris).

Assessment of the developmental success of Anopheles coluzzii larvae under different nutrient regimes: effects of diet quality, food amount and larval density. (2018)
Journal Article
(2018). Assessment of the developmental success of Anopheles coluzzii larvae under different nutrient regimes: effects of diet quality, food amount and larval density. Malaria Journal, 377. https://doi.org/10.1186/s12936-018-2530-z

BACKGROUND: In a context of increasing resistance of both vectors toward main classes of insecticides used in public health and parasites toward anti-malarial drugs, development of new and complementary molecules or control approaches is fundamental... Read More about Assessment of the developmental success of Anopheles coluzzii larvae under different nutrient regimes: effects of diet quality, food amount and larval density..

Simultaneous Detection of Ammonium and Nitrate in Environmental Samples Using on Ion-Selective Electrode and Comparison with Portable Colorimetric Assays (2018)
Journal Article
(2018). Simultaneous Detection of Ammonium and Nitrate in Environmental Samples Using on Ion-Selective Electrode and Comparison with Portable Colorimetric Assays. Sensors, https://doi.org/10.3390/s18103555

Simple, robust, and low-cost nitrate- and ammonium-selective electrodes were made using substrate prepared from household materials. We explored phosphonium-based ILs and poly (methyl methacrylate)/poly(decyl methacrylate)(MMA-DMA) copolymer as matri... Read More about Simultaneous Detection of Ammonium and Nitrate in Environmental Samples Using on Ion-Selective Electrode and Comparison with Portable Colorimetric Assays.

Is callose required for silicification in plants? (2018)
Journal Article
(2018). Is callose required for silicification in plants?. Biology Letters, https://doi.org/10.1098/rsbl.2018.0338

The cell wall polymer callose catalyses the formation of silica in vitro and is heavily implicated in biological silicification in Equisetum (horsetail) and Arabidopsis (thale cress) in vivo Callose, a ß-1,3-glucan, is an ideal partner for silicifica... Read More about Is callose required for silicification in plants?.

Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation. (2018)
Journal Article
(2018). Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation. Nature communications, 4015 - ?. https://doi.org/10.1038/s41467-018-06307-w

In the adult auditory organ, mechanoelectrical transducer (MET) channels are essential for transducing acoustic stimuli into electrical signals. In the absence of incoming sound, a fraction of the MET channels on top of the sensory hair cells are ope... Read More about Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation..

Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation (2018)
Journal Article
(2018). Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation. Nature communications, https://doi.org/10.1038/s41467-018-06307

In the adult auditory organ, mechanoelectrical transducer (MET) channels are essential for transducing acoustic stimuli into electrical signals. In the absence of incoming sound, a fraction of the MET channels on top of the sensory hair cells are ope... Read More about Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation.