Outputs (91)

Soil compaction effects on grassland silage yields and soil structure under different levels of compaction over three years (2019)
Journal Article
Hargreaves, P., Baker, K., Graceson, A., Bonnett, S., Ball, B., & Cloy, J. (2019). Soil compaction effects on grassland silage yields and soil structure under different levels of compaction over three years. European Journal of Agronomy, 109, Article 125916. https://doi.org/10.1016/j.eja.2019.125916

Soil compaction has been estimated to be responsible for 33 million ha of soil degradation in Europe, reducing crop yields, however there is limited data on grassland silage yields loss. Extended grazing periods, increased size and weight of farm veh... Read More about Soil compaction effects on grassland silage yields and soil structure under different levels of compaction over three years.

Atomic-resolution crystal structures of the immune protein conglutinin from cow reveal specific interactions of its binding site with N-acetylglucosamine. (2019)
Journal Article
Paterson, J. M., Shaw, A. J., Burns, I., Dodds, A. W., Prasad, A., Reid, K. B., …Shrive, A. K. (2019). Atomic-resolution crystal structures of the immune protein conglutinin from cow reveal specific interactions of its binding site with N-acetylglucosamine. Journal of biological chemistry, 294(45), 17155-17165. https://doi.org/10.1074/jbc.RA119.010271

Bovine conglutinin is an immune protein that is involved in host resistance to microbes and parasites and interacts with complement component iC3b, agglutinates erythrocytes, and neutralizes influenza A virus. Here, we determined the high-resolution... Read More about Atomic-resolution crystal structures of the immune protein conglutinin from cow reveal specific interactions of its binding site with N-acetylglucosamine..

Tools for the Quality Control of Pharmaceutical Heparin. (2019)
Journal Article
Devlin, A., Mycroft-West, C., Procter, P., Cooper, L., Guimond, S., Andrade De Lima, M., …Skidmore, M. (2019). Tools for the Quality Control of Pharmaceutical Heparin. Medicina, 55, 636 - 636. https://doi.org/10.3390/medicina55100636

Heparin is a vital pharmaceutical anticoagulant drug and remains one of the few naturally sourced pharmaceutical agents used clinically. Heparin possesses a structural order with up to four levels of complexity. These levels are subject to change bas... Read More about Tools for the Quality Control of Pharmaceutical Heparin..

A Tmc1 mutation reduces calcium permeability and expression of mechanoelectrical transduction channels in cochlear hair cells. (2019)
Journal Article
(2019). A Tmc1 mutation reduces calcium permeability and expression of mechanoelectrical transduction channels in cochlear hair cells. Proceedings of the National Academy of Sciences of the United States of America, 20743-20749. https://doi.org/10.1073/pnas.1908058116

Mechanoelectrical transducer (MET) currents were recorded from cochlear hair cells in mice with mutations of transmembrane channel-like protein TMC1 to study the effects on MET channel properties. We characterized a Tmc1 mouse with a single-amino-aci... Read More about A Tmc1 mutation reduces calcium permeability and expression of mechanoelectrical transduction channels in cochlear hair cells..

Quantifying the potential for bluetongue virus transmission in Danish cattle farms (2019)
Journal Article
Haider, N., Kjær, L. J., Skovgård, H., Nielsen, S. A., & Bødker, R. (2019). Quantifying the potential for bluetongue virus transmission in Danish cattle farms. Scientific reports, 9, Article 13466. https://doi.org/10.1038/s41598-019-49866-8

<jats:title>Abstract</jats:title> <jats:p>We used a mechanistic transmission model to estimate the number of infectious bites (IBs) generated per bluetongue virus (BTV) infected host (cattle) using estimated hourly microclimatic temperatures at 22,00... Read More about Quantifying the potential for bluetongue virus transmission in Danish cattle farms.

Semi-field and indoor setups to study malaria mosquito swarming behavior (2019)
Journal Article
(2019). Semi-field and indoor setups to study malaria mosquito swarming behavior. Parasites and Vectors, 446 -?. https://doi.org/10.1186/s13071-019-3688-0

BACKGROUND
The recent resurgence of interest in sterile insect techniques to control vector mosquitoes has renewed interest in novel methods for observing mating behavior. Malarial vectors of the Anopheles gambiae complex are known to mate in swarms... Read More about Semi-field and indoor setups to study malaria mosquito swarming behavior.

BioStruct-Africa: empowering Africa-based scientists through structural biology knowledge transfer and mentoring - recent advances and future perspectives. (2019)
Journal Article
(2019). BioStruct-Africa: empowering Africa-based scientists through structural biology knowledge transfer and mentoring - recent advances and future perspectives. Journal of Synchrotron Radiation, 1843 -1850. https://doi.org/10.1107/S1600577519008981

Being able to visualize biology at the molecular level is essential for our understanding of the world. A structural biology approach reveals the molecular basis of disease processes and can guide the design of new drugs as well as aid in the optimiz... Read More about BioStruct-Africa: empowering Africa-based scientists through structural biology knowledge transfer and mentoring - recent advances and future perspectives..

Unequivocal imaging of aluminium in human cells and tissues by an improved method using morin. (2019)
Journal Article
(2019). Unequivocal imaging of aluminium in human cells and tissues by an improved method using morin. Histochemistry and Cell Biology, https://doi.org/10.1007/s00418-019-01809-0

Aluminium is biologically reactive and its ability to potentiate the immune response has driven its inclusion in both veterinary and human vaccines. Consequently, the need for unequivocal visualisation of aluminium in vivo has created a focused resea... Read More about Unequivocal imaging of aluminium in human cells and tissues by an improved method using morin..

Crude Heparin Preparations Unveil the Presence of Structurally Diverse Oversulfated Contaminants (2019)
Journal Article
Mendes, A., Meneghetti, M., Palladino, M., Justo, G., Sassaki, G., Fareed, J., …Nader, H. (2019). Crude Heparin Preparations Unveil the Presence of Structurally Diverse Oversulfated Contaminants. Molecules, 24, 2988--2988. https://doi.org/10.3390/molecules24162988

Nowadays, pharmaceutical heparin is purified from porcine and bovine intestinal mucosa. In the past decade there has been an ongoing concern about the safety of heparin, since in 2008, adverse effects associated with the presence of an oversulfated c... Read More about Crude Heparin Preparations Unveil the Presence of Structurally Diverse Oversulfated Contaminants.

The size of micro-crystalline tyrosine (MCT®) influences its recognition and uptake by THP-1 macrophages in vitro (2019)
Journal Article
(2019). The size of micro-crystalline tyrosine (MCT®) influences its recognition and uptake by THP-1 macrophages in vitro. RSC advances, 24505 - 24518. https://doi.org/10.1039/C9RA03831K

The physicochemical hallmarks of particulate immunopotentiators play a pivotal role with regards to their adjuvanticity in vivo. These properties have not been fully characterised in the case of MCT®, an amino acid-based adjuvant used as an alternati... Read More about The size of micro-crystalline tyrosine (MCT®) influences its recognition and uptake by THP-1 macrophages in vitro.