Deciphering the ubiquitin-mediated pathway in apicomplexan parasites: a potential strategy to interfere with parasite virulence
Reversible modification of proteins through the attachment of ubiquitin or ubiquitin-like modifiers is an essential post-translational regulatory mechanism in eukaryotes. The conjugation of ubiquitin or ubiquitin-like proteins has been demonstrated to play roles in growth, adaptation and homeostasis in all eukaryotes, with perturbation of ubiquitin-mediated systems associated with the pathogenesis of many human diseases, including cancer and neurodegenerative disorders.
|Acceptance Date||Apr 24, 2008|
|Publication Date||Apr 24, 2008|
|Publisher||Public Library of Science|
|Pages||e2386 - ?|
|Keywords||Apicomplexa, Plasmodium, Protein domains, Toxoplasma gondii, Ligases, Ubiquitin ligases, Cell cycle and cell division, Conjugated proteins|
Deciphering the ubiquitin-mediated pathway in apicomplexan parasites: a potential strategy to interfere with parasite virulence..pdf
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