Horrocks
Deciphering the ubiquitin-mediated pathway in apicomplexan parasites: a potential strategy to interfere with parasite virulence
Horrocks
Authors
Abstract
Reversible modification of proteins through the attachment of ubiquitin or ubiquitin-like modifiers is an essential post-translational regulatory mechanism in eukaryotes. The conjugation of ubiquitin or ubiquitin-like proteins has been demonstrated to play roles in growth, adaptation and homeostasis in all eukaryotes, with perturbation of ubiquitin-mediated systems associated with the pathogenesis of many human diseases, including cancer and neurodegenerative disorders.
| Acceptance Date | Apr 24, 2008 |
|---|---|
| Publication Date | Apr 24, 2008 |
| Journal | PLoS One |
| Print ISSN | 1932-6203 |
| Publisher | Public Library of Science |
| Pages | e2386 - ? |
| DOI | https://doi.org/10.1371/journal.pone.0002386 |
| Keywords | Apicomplexa, Plasmodium, Protein domains, Toxoplasma gondii, Ligases, Ubiquitin ligases, Cell cycle and cell division, Conjugated proteins |
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