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Natural variations in egg hatching behaviour and selection of novel slowhatching strains for male anopheline deployment (2023)
Thesis

Genetic Mosquito mass release is a promising tool in the suppression of wild Anopheles gambiae sensu lato mosquitoes as part of malaria control in Africa. This tool requires a plethora number of eggs and a strain with good fitness. Thus, the success... Read More about Natural variations in egg hatching behaviour and selection of novel slowhatching strains for male anopheline deployment.

Single-cell profiling of Anopheles gambiae spermatogenesis defines the onset of meiotic silencing and premeiotic overexpression of the X chromosome (2023)
Journal Article

Understanding development and genetic regulation in the Anopheles gambiae germline is essential to engineer effective genetic control strategies targeting this malaria mosquito vector. These include targeting the germline to induce sterility or using... Read More about Single-cell profiling of Anopheles gambiae spermatogenesis defines the onset of meiotic silencing and premeiotic overexpression of the X chromosome.

Magnetic activation of TREK1 triggers stress signalling and regulates neuronal branching in SH-SY5Y cells. (2022)
Journal Article

TWIK-related K+ 1 (TREK1) is a potassium channel expressed in the nervous system with multiple functions including neurotransmission and is a prime pharmacological target for neurological disorders. TREK1 gating is controlled by a wide range of exter... Read More about Magnetic activation of TREK1 triggers stress signalling and regulates neuronal branching in SH-SY5Y cells..

A preliminary study into the impact of using three-dimensional models in forensic anthropology learning and teaching. (2022)
Journal Article

Forensic anthropology has traditionally relied on two-dimensional (2D) images, such as photographs and sketches, to perform analyses, and disseminate findings. However, as 3D imaging technology advances, it has become more widely implemented into for... Read More about A preliminary study into the impact of using three-dimensional models in forensic anthropology learning and teaching..

A requirement for astrocyte IP3R2 signaling for whisker experience-dependent depression and homeostatic upregulation in the mouse barrel cortex. (2022)
Journal Article

Changes to sensory experience result in plasticity of synapses in the cortex. This experience-dependent plasticity (EDP) is a fundamental property of the brain. Yet, while much is known about neuronal roles in EDP, very little is known about the role... Read More about A requirement for astrocyte IP3R2 signaling for whisker experience-dependent depression and homeostatic upregulation in the mouse barrel cortex..

Non-anticoagulant glycosaminoglycan extracts isolated from aquatic species inhibit BACE-1: a key drug target in Alzheimer’s Disease (2022)
Thesis

Currently, only palliative drugs are available for the treatment of Alzheimer’s disease, therefore there is an urgent need to develop therapeutics targeting the underlying aetiology of the disease. The clinical anticoagulant heparin has previously be... Read More about Non-anticoagulant glycosaminoglycan extracts isolated from aquatic species inhibit BACE-1: a key drug target in Alzheimer’s Disease.

An in vitro study into the effects of erastin in the SH-SY5Y cell line, as a model of Parkinson’s disease (2022)
Thesis

Ferroptosis is a non-apoptotic, iron-dependent cell death pathway first identified in an engineered tumorigenic cell line in 2012. Hallmark characteristics include direct or indirect loss of functional GPX4 enzymes, resulting in depletion of glutathi... Read More about An in vitro study into the effects of erastin in the SH-SY5Y cell line, as a model of Parkinson’s disease.

Exploring the use of attractive sugar bait stations to deliver antiplasmodial compounds to Anopheles mosquitoes (2022)
Thesis

Between 2000 and 2015, Sub-Saharan Africa made historic process against the scourge of malaria. Since this time there has been a plateau in the number of malaria cases and mortalities. The decreasing efficacy of the current methods used against this... Read More about Exploring the use of attractive sugar bait stations to deliver antiplasmodial compounds to Anopheles mosquitoes.

Enamel growth rate variation of inner, mid, and outer enamel regions between select permanent tooth types across five temporally distinct British samples (2022)
Journal Article

Objective This study explored differences in the regional daily growth rates of human enamel between tooth types across a temporal transect in Britain. Methods Upper permanent central incisors (n = 81), upper permanent canines (n = 69), and upper and... Read More about Enamel growth rate variation of inner, mid, and outer enamel regions between select permanent tooth types across five temporally distinct British samples.

Blood biochemical parameters as predictors of disease severity and mortality in COVID-19 patients- an updated systematic review and meta-analysis (2021)
Other

ABSTRACT Background The outbreak of coronavirus disease 2019 (COVID-19) has been rapidly spreading across the globe and poses a great risk to human health. Patients with abnormalities in laboratory parameters are more susceptible to COVID-19. Therefo... Read More about Blood biochemical parameters as predictors of disease severity and mortality in COVID-19 patients- an updated systematic review and meta-analysis.

ApoE and ApoE Nascent-Like HDL Particles at Model Cellular Membranes: Effect of Protein Isoform and Membrane Composition. (2021)
Journal Article

Apolipoprotein E (ApoE), an important mediator of lipid transportation in plasma and the nervous system, plays a large role in diseases such as atherosclerosis and Alzheimer's. The major allele variants ApoE3 and ApoE4 differ only by one amino acid.... Read More about ApoE and ApoE Nascent-Like HDL Particles at Model Cellular Membranes: Effect of Protein Isoform and Membrane Composition..