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Investigation into the mechanistic effects of the lncRNA Growth Arrest Specific 5 in the regulation of cell survival (2024)
Thesis
Maroszek, M. R. Investigation into the mechanistic effects of the lncRNA Growth Arrest Specific 5 in the regulation of cell survival. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/884975

Current research indicates that long noncoding RNAs orchestrate various regulatory processes in a physiological context and thereby, their dysregulation may contribute to major human diseases, including cancer (Grammatikakis et al.,2014).

Long no... Read More about Investigation into the mechanistic effects of the lncRNA Growth Arrest Specific 5 in the regulation of cell survival.

Screening of an open-source compound library against the livestock parasite Trypanosoma evansi (2024)
Thesis
Ansah, M. L. K. (2024). Screening of an open-source compound library against the livestock parasite Trypanosoma evansi. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/853242

Surra is a neglected tropical veterinary disease that causes a large socioeconomic burden in sub-Saharan Africa, South America, the middle east, Asia, and parts of Southern Europe. Although symptoms can be mild in wild animal species, disease in dome... Read More about Screening of an open-source compound library against the livestock parasite Trypanosoma evansi.

Investigating multiple factors affecting the successful infection and transmission of arboviruses (2024)
Thesis
Widlake, E. (2024). Investigating multiple factors affecting the successful infection and transmission of arboviruses. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/850302

Arboviruses are arthropod-borne viruses that cycle between a vertebrate host and an arthropod vector. This disparate life cycle involves adapting to two alternate animals and the differing tissues and systems within them. A range of factors influence... Read More about Investigating multiple factors affecting the successful infection and transmission of arboviruses.

Evaluation of Nanopore sequencing for interrogating mosquito pools from surveillance systems (2024)
Thesis
Nascimento, C. L. D. (2024). Evaluation of Nanopore sequencing for interrogating mosquito pools from surveillance systems. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/853170

Vector-borne diseases are responsible for 17% of all infectious diseases worldwide and contribute to more than 700 000 deaths annually, mainly in sub-Saharan countries. Vector surveillance is a crucial element of vector control programmes to assure t... Read More about Evaluation of Nanopore sequencing for interrogating mosquito pools from surveillance systems.

Evaluating the antiplasmodial activity of synthetic and natural product libraries against intraerythrocytic Plasmodium falciparum (2024)
Thesis
Mobley, R. M. (2024). Evaluating the antiplasmodial activity of synthetic and natural product libraries against intraerythrocytic Plasmodium falciparum. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/853179

Malaria continues to cause great global health concerns despite efforts for control and elimination. The emergence of resistance to components of the frontline artemisinin combination therapy highlights the urgent need for novel malaria therapeutics... Read More about Evaluating the antiplasmodial activity of synthetic and natural product libraries against intraerythrocytic Plasmodium falciparum.

Cell therapy to treat knee cartilage defects - transcriptome exploration of autologous mesenchymal stromal cells and chondrocytes (2024)
Thesis
Tierney, L. J. (2024). Cell therapy to treat knee cartilage defects - transcriptome exploration of autologous mesenchymal stromal cells and chondrocytes. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/775433

Autologous chondrocyte implantation (ACI) has repeatedly been shown to be an effective treatment for cartilage defects within the knee and can delay or prevent the need for a total knee replacement. However, the level of clinical benefit experienced... Read More about Cell therapy to treat knee cartilage defects - transcriptome exploration of autologous mesenchymal stromal cells and chondrocytes.

Natural variations in egg hatching behaviour and selection of novel slowhatching strains for male anopheline deployment (2023)
Thesis
Ottih, E. C. (2023). Natural variations in egg hatching behaviour and selection of novel slowhatching strains for male anopheline deployment. (Thesis). Keele University

Genetic Mosquito mass release is a promising tool in the suppression of wild Anopheles gambiae sensu lato mosquitoes as part of malaria control in Africa. This tool requires a plethora number of eggs and a strain with good fitness. Thus, the success... Read More about Natural variations in egg hatching behaviour and selection of novel slowhatching strains for male anopheline deployment.

Single-cell profiling of Anopheles gambiae spermatogenesis defines the onset of meiotic silencing and premeiotic overexpression of the X chromosome (2023)
Journal Article
Page, N., Taxiarchi, C., Tonge, D., Kuburic, J., Chesters, E., Kriezis, A., …Galizi, R. (2023). Single-cell profiling of Anopheles gambiae spermatogenesis defines the onset of meiotic silencing and premeiotic overexpression of the X chromosome. Communications Biology, 6(1), Article 850. https://doi.org/10.1038/s42003-023-05224-z

Understanding development and genetic regulation in the Anopheles gambiae germline is essential to engineer effective genetic control strategies targeting this malaria mosquito vector. These include targeting the germline to induce sterility or using... Read More about Single-cell profiling of Anopheles gambiae spermatogenesis defines the onset of meiotic silencing and premeiotic overexpression of the X chromosome.

In-solution and interface study on biological model membranes and their interaction with Prohibitin (2023)
Thesis
Piccinini, A. (2023). In-solution and interface study on biological model membranes and their interaction with Prohibitin. (Thesis). Keele University

Prohibitins (PHB) play a crucial role in premature cellular ageing, tumour suppression, cell cycle regulation, and apoptosis, and their deregulation is involved in viral infections, neurological and cardiovascular diseases and cancer. Despite the ess... Read More about In-solution and interface study on biological model membranes and their interaction with Prohibitin.

Study to determine the rate of kill of anti-leishmanial drugs using a novel bioluminescence-based assay (2023)
Thesis
Freakley, A. L. (2023). Study to determine the rate of kill of anti-leishmanial drugs using a novel bioluminescence-based assay. (Thesis). Keele University

Leishmaniasis is a neglected tropical disease associated with poverty, deprived socio-economic settings and population displacement, primarily due to conflict. The causative agent are species of Leishmania parasites that are transmitted by sand flies... Read More about Study to determine the rate of kill of anti-leishmanial drugs using a novel bioluminescence-based assay.

Magnetic activation of TREK1 triggers stress signalling and regulates neuronal branching in SH-SY5Y cells. (2022)
Journal Article
Rotherham, M., Moradi, Y., Nahar, T., Mosses, D., Telling, N., & El Haj, A. (2022). Magnetic activation of TREK1 triggers stress signalling and regulates neuronal branching in SH-SY5Y cells. Frontiers in Medical Technology, 4, Article 981421. https://doi.org/10.3389/fmedt.2022.981421

TWIK-related K+ 1 (TREK1) is a potassium channel expressed in the nervous system with multiple functions including neurotransmission and is a prime pharmacological target for neurological disorders. TREK1 gating is controlled by a wide range of exter... Read More about Magnetic activation of TREK1 triggers stress signalling and regulates neuronal branching in SH-SY5Y cells..

Biological Flora of Britain and Ireland: Viscum album (2022)
Journal Article
Thomas, P. A., Dering, M., Giertych, M. J., Iszkuło, G., Tomaszewski, D., & Briggs, J. (2022). Biological Flora of Britain and Ireland: Viscum album. Journal of Ecology, 111(3), 701-739. https://doi.org/10.1111/1365-2745.14036

This account presents information on all aspects of the biology of Viscum album L. (Mistletoe) that are relevant to understanding its ecological characteristics and behaviour. The main topics are presented within the standard framework of the Biologi... Read More about Biological Flora of Britain and Ireland: Viscum album.

A preliminary study into the impact of using three-dimensional models in forensic anthropology learning and teaching. (2022)
Journal Article
Collings, A., & Craik, K. (2022). A preliminary study into the impact of using three-dimensional models in forensic anthropology learning and teaching. Science and Justice, 814 - 821. https://doi.org/10.1016/j.scijus.2022.04.006

Forensic anthropology has traditionally relied on two-dimensional (2D) images, such as photographs and sketches, to perform analyses, and disseminate findings. However, as 3D imaging technology advances, it has become more widely implemented into for... Read More about A preliminary study into the impact of using three-dimensional models in forensic anthropology learning and teaching..

Vertical and Horizontal Transmission of Cell Fusing Agent Virus in Aedes aegypti (2022)
Journal Article
Logan, R., Quek, S., Muthoni, J., von Eicken, A., Brettell, L., Anderson, E., …Patterson, E. (2022). Vertical and Horizontal Transmission of Cell Fusing Agent Virus in Aedes aegypti. Applied and Environmental Microbiology, https://doi.org/10.1128/aem.01062-22

Cell fusing agent virus (CFAV) is an insect-specific flavivirus (ISF) found in Aedes aegypti mosquitoes. ISFs have demonstrated the ability to modulate the infection or transmission of arboviruses such as dengue, West Nile, and Zika viruses. It is th... Read More about Vertical and Horizontal Transmission of Cell Fusing Agent Virus in Aedes aegypti.

A requirement for astrocyte IP3R2 signaling for whisker experience-dependent depression and homeostatic upregulation in the mouse barrel cortex. (2022)
Journal Article
Butcher, J., Sims, R., Ngum, N., Bazzari, A. H., Jenkins, S. I., King, M., …Glazewski. (2022). A requirement for astrocyte IP3R2 signaling for whisker experience-dependent depression and homeostatic upregulation in the mouse barrel cortex. Frontiers in Cellular Neuroscience, 16, Article 905285. https://doi.org/10.3389/fncel.2022.905285

Changes to sensory experience result in plasticity of synapses in the cortex. This experience-dependent plasticity (EDP) is a fundamental property of the brain. Yet, while much is known about neuronal roles in EDP, very little is known about the role... Read More about A requirement for astrocyte IP3R2 signaling for whisker experience-dependent depression and homeostatic upregulation in the mouse barrel cortex..

Hands-on training in structural biology, a tool for sustainable development in Africa series 4. (2022)
Journal Article
(2022). Hands-on training in structural biology, a tool for sustainable development in Africa series 4. Biology open BiO / Company of Biologists, 1-4. https://doi.org/10.1242/bio.059487

Structural biology is an essential tool for understanding the molecular basis of diseases, which can guide the rational design of new drugs, vaccines, and the optimisation of existing medicines. However, most African countries do not conduct structur... Read More about Hands-on training in structural biology, a tool for sustainable development in Africa series 4..

Stem cell-based therapy for human diseases. (2022)
Journal Article
Hoang, D., Pham, P., Bach, T., Ngo, A., Nguyen, Q., Phan, T., …Heke, M. (2022). Stem cell-based therapy for human diseases. Signal Transduction and Targeted Therapy, 272 - ?. https://doi.org/10.1038/s41392-022-01134-4

Recent advancements in stem cell technology open a new door for patients suffering from diseases and disorders that have yet to be treated. Stem cell-based therapy, including human pluripotent stem cells (hPSCs) and multipotent mesenchymal stem cells... Read More about Stem cell-based therapy for human diseases..

Non-anticoagulant glycosaminoglycan extracts isolated from aquatic species inhibit BACE-1: a key drug target in Alzheimer’s Disease (2022)
Thesis
Mycroft-West, C. J. (2022). Non-anticoagulant glycosaminoglycan extracts isolated from aquatic species inhibit BACE-1: a key drug target in Alzheimer’s Disease. (Thesis). Keele University

Currently, only palliative drugs are available for the treatment of Alzheimer’s disease, therefore there is an urgent need to develop therapeutics targeting the underlying aetiology of the disease. The clinical anticoagulant heparin has previously be... Read More about Non-anticoagulant glycosaminoglycan extracts isolated from aquatic species inhibit BACE-1: a key drug target in Alzheimer’s Disease.

An in vitro study of the modulation of astrocytes in the blood brain barrier during human cerebral malaria (2022)
Thesis
Ogbolosingha, A. J. (2022). An in vitro study of the modulation of astrocytes in the blood brain barrier during human cerebral malaria. (Thesis). Keele University

Cerebral malaria (CM) is the most life-threatening complication of Plasmodium falciparum (Pf) infection. A key hallmark of CM is the sequestration of Pf infected red blood cells (PRBC) to the human brain endothelial cells (HBEC) of the blood brain ba... Read More about An in vitro study of the modulation of astrocytes in the blood brain barrier during human cerebral malaria.