A synthesis of C-glycosidic multivalent mannosides suitable for divergent functionalized conjugation

Miller

Abstract

Divergent synthesis of two novel C-glycosidic multivalent mannosides derived from a common trivalent C-mannosyl carboxylate-terminated intermediate is described. This illustrates synthesis of multivalent C-glycosidic architectures bearing variable extended functionalized tethers. One such tether incorporates an embedded fluorescent unit providing a C-mannosyl multivalent epitope offering potential applications through further conjugation or immobilization.

Citation

Miller. (2011). A synthesis of C-glycosidic multivalent mannosides suitable for divergent functionalized conjugation. Tetrahedron Letters, 3216 - 3218. https://doi.org/10.1016/j.tetlet.2011.04.047

• Acceptance Date: Apr 11, 2011
• Publication Date: Apr 18, 2011
• Journal: Tetrahedron Letters
• Print ISSN: 0040-4039
• Publisher: Elsevier
• Pages: 3216 - 3218
• DOI: https://doi.org/10.1016/j.tetlet.2011.04.047
• Keywords: C-Glycosides, Multivalency, Carbohydrates, Glycobiology, Glycoconjugation
• Publisher URL: https://doi.org/10.1016/j.tetlet.2011.04.047