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Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology

Jayson, Gordon C.; Hansen, Steen U.; Miller, Gavin J.; Cole, Claire L.; Rushton, Graham; Avizienytea, Egle; Gardiner, John M.

Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology Thumbnail


Authors

Gordon C. Jayson

Steen U. Hansen

Claire L. Cole

Graham Rushton

Egle Avizienytea

John M. Gardiner



Abstract

he multigram-scale synthesis of a sulfation-site programmed heparin-like dodecasaccharide is described. Evaluation alongside dodecasaccharides lacking this single glucosamine O6-sulfation, or having per-O6-sulfation, shows that site-specific modification of the terminal glucosamine dramatically interconverts regulation of in vitro and in vivo biology mediated by the two important chemokines, CXCL12 (SDF1a) or CXCL8 (IL-8).

Journal Article Type Article
Acceptance Date Jul 22, 2015
Publication Date Jul 22, 2015
Journal Chemical Communications
Print ISSN 1359-7345
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 51
Issue 72
Pages 13846 -13849
DOI https://doi.org/10.1039/c5cc05222j
Publisher URL http://dx.doi.org/10.1039/c5cc05222j

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