A latent reactive handle for functionalising heparin-like and LMWH deca- and dodecasaccharides

Miller

Abstract

D-Glucosamine derivatives bearing latent O4 functionality provide modified H/HS-type disaccharide donors for a final stage capping approach enabling introduction of conjugation-suitable, non-reducing terminal functionality to biologically important glycosaminoglycan oligosaccharides. Application to the synthesis of the first O4-terminus modified synthetic LMWH decasaccharide and an HS-like dodecasaccharide is reported.

Citation

Miller, Miller, G. J., Broberg, K. R., Rudd, C., Helliwell, M. R., Jayson, G. C., & Gardiner, J. M. (2015). A latent reactive handle for functionalising heparin-like and LMWH deca- and dodecasaccharides. Organic and Biomolecular Chemistry, 13(46), 11208-11219. https://doi.org/10.1039/c5ob01706h

• Journal Article Type: Article
• Acceptance Date: Sep 9, 2015
• Publication Date: Sep 9, 2015
• Journal: Organic & Biomolecular Chemistry
• Print ISSN: 1477-0520
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 13
• Issue: 46
• Pages: 11208-11219
• DOI: https://doi.org/10.1039/c5ob01706h
• Publisher URL: http://dx.doi.org/10.1039/c5ob01706h