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Gout characteristics associate with depression, but not anxiety, in primary care: Baseline findings from a prospective cohort study

Prior, James A; Mallen, Christian; Chandratre, Priyanka; Muller, Sara; Richardson, Jane; Roddy, Ed

Gout characteristics associate with depression, but not anxiety, in primary care: Baseline findings from a prospective cohort study Thumbnail


Christian Mallen

Priyanka Chandratre

Jane Richardson


OBJECTIVES: To determine the prevalence of anxiety and depression in gout, examine associations between gout characteristics and these comorbidities and determine the role of allopurinol in any such relationships. METHOD: As part of a prospective cohort study, a baseline questionnaire was sent to 1805 participants with gout aged=18 years from UK primary care. Participants had a gout diagnosis or prescriptions for allopurinol or colchicine in their medical records 2 years prior to baseline. Prevalence of anxiety was defined using the Generalised Anxiety Disorder questionnaire and depression using the Patient Health Questionnaire. Logistic regression was used to examine any association between gout characteristics (12-month attack frequency, oligo/polyarticular gout and gout duration) and the presence of anxiety or depression. Crude and adjusted associations were reported as odds ratios (OR) and 95% confidence intervals (CI). Adjusted gout characteristics were stratified by allopurinol use. RESULTS: One thousand one hundred and eighty-four participants responded to baseline (65.6%). Prevalence of anxiety and depression were 10.0% and 12.6% respectively. There was no association between gout characteristics and anxiety. However, there was an association between attack frequency and depression amongst those gout patients using allopurinol (2.87 [1.2 to 6.6]) and also between oligo/polyarticular gout and depression (2.01 [1.2 to 3.3]), irrespective of allopurinol use (2.09 [1.1 to 4.0]) or not (2.64 [1.0 to 6.8]). CONCLUSION: Patients experiencing frequent gout attacks or attacks in multiple joints are likely to experience depressive symptoms, even when using allopurinol. Depression may influence medication adherence and participation in routine reviews, hence impacting adversely on gout management outcomes.

Journal Article Type Article
Acceptance Date Oct 19, 2015
Online Publication Date Apr 7, 2016
Publication Date 2016-10
Publicly Available Date May 26, 2023
Journal Joint Bone Spine
Print ISSN 1297-319X
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 83
Issue 5
Pages 553-558
Keywords allopurinol; anxiety; comorbidity; depression; gout; primary care
Publisher URL


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