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Gout - a guide for the general and acute physicians.


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Gout is the most prevalent inflammatory arthritis and affects 2.5% of the general population in the UK. It is also the only arthritis that has the potential to be cured with safe, inexpensive and well tolerated urate-lowering treatments, which reduce serum uric acid by either inhibiting xanthine oxidase - eg allopurinol, febuxostat - or by increasing the renal excretion of uric acid. Of these, xanthine oxidase inhibitors are used first line and are effective in 'curing' gout in the vast majority of patients. Gout can be diagnosed on clinical grounds in those with typical podagra. However, in those with involvement of other joints, joint aspiration is recommended to demonstrate monosodium urate crystals and exclude other causes of acute arthritis, such as septic arthritis. However, a clinical diagnosis of gout can be made if joint aspiration is not feasible. This review summarises the current understanding of the pathophysiology, clinical presentation, investigations and treatment of gout.

Acceptance Date Feb 1, 2017
Publication Date Feb 1, 2017
Journal Clinical Medicine
Print ISSN 1470-2118
Publisher Royal College of Physicians
Pages 54 - 59
Keywords colchicine; gout; hyperuricemia; tophi; urate-lowering treatment
Publisher URL


E Roddy - Gout - a guide for the general and acute physicians.pdf (302 Kb)

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