Skip to main content

Research Repository

Advanced Search

The symptomatic course of foot osteoarthritis phenotypes: an 18-month prospective analysis of community-dwelling older adults.

Downes, Thomas J.; Chesterton, Linda; Whittle, Rebecca; Roddy, Ed; Menz, Hylton B.; Marshall, Michelle; Thomas, Martin J.

The symptomatic course of foot osteoarthritis phenotypes: an 18-month prospective analysis of community-dwelling older adults. Thumbnail


Authors

Thomas J. Downes

Linda Chesterton

Rebecca Whittle

Hylton B. Menz



Abstract

OBJECTIVE: Osteoarthritis (OA) is a heterogeneous disease with symptom progression at the foot unclear. This study investigated the symptomatic course of three pre-defined foot OA phenotypes over an 18-month period. METHODS: The Clinical Assessment Study of the Foot (CASF) is a community-based cohort of adults aged =50 years in North Staffordshire, UK. Participants who reported foot pain in a postal health survey and underwent radiographic assessment were mailed an 18-month follow-up survey. Changes in descriptive and symptomatic outcomes over 18 months were compared across the three phenotypes to determine within-phenotype changes and between-phenotype differences. RESULTS: Of 533 participants at baseline, 478 (89.7%) responded at 18 months. All three phenotypes showed small within-phenotype improvements in mean foot pain severity (scale from 0=no pain to 10=worst pain): no or minimal foot OA (18-month 4.0; mean change -1.15 [95% CI -1.46,-0.83]), isolated first metatarsophalangeal joint (MTPJ) OA (18-month 4.1; mean change -0.60 [95% CI -1.11,-0.10]) and polyarticular foot OA (18-month 5.1; mean change -0.77 [95% CI -1.42,-0.12]). The isolated first MTPJ OA phenotype had an increased likelihood of hallux valgus in the left foot (adjusted odds ratio 2.96 [95% CI 1.23,7.12]) compared to the no or minimal foot OA phenotype. CONCLUSION: Three foot OA phenotypes showed few descriptive or symptomatic changes over 18 months. Future clinical trials should consider that people recruited with mild-to-moderate symptomatic foot OA appear likely to remain relatively stable with usual care. Longer-term follow-up using additional time-points is required to describe further the natural history of foot OA. This article is protected by copyright. All rights reserved.

Citation

Downes, T. J., Chesterton, L., Whittle, R., Roddy, E., Menz, H. B., Marshall, M., & Thomas, M. J. (2018). The symptomatic course of foot osteoarthritis phenotypes: an 18-month prospective analysis of community-dwelling older adults. Arthritis Care and Research, 70(7), 1107-1112. https://doi.org/10.1002/acr.23502

Journal Article Type Article
Acceptance Date Dec 19, 2017
Online Publication Date Dec 29, 2017
Publication Date 2018-07
Journal Arthritis Care and Research
Print ISSN 2151-464X
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 70
Issue 7
Pages 1107-1112
DOI https://doi.org/10.1002/acr.23502
Publisher URL http://onlinelibrary.wiley.com/doi/10.1002/acr.23502/abstract;jsessionid=0090AFFD05F14559FF160B0DA6995F57.f01t03

Files






You might also like



Downloadable Citations