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Exploiting Inherent Instability of 2D Black Phosphorus for Controlled Phosphate Release from Blow-Spun Poly (lactide-co-glycolide) Nanofibers

Kamyar, N; Greenhalgh, R; Nascimento, T; Medeiros, E; Matthews, P; Nogueira, L; Haugen, HJ; Lewis, DJ; Blaker, JJ

Authors

N Kamyar

R Greenhalgh

T Nascimento

E Medeiros

L Nogueira

HJ Haugen

DJ Lewis

JJ Blaker



Abstract

Efforts have been made to stabilize black phosphorus (BP) to utilize its tunable band gap and anisotropic mechanical properties. Here, the intrinsic instability of BP is exploited for controlled therapeutic ion release, namely phosphate. BP was incorporated into degradable poly (lactide-co-glycolide) fibers via solution blow spinning. Raman spectroscopy confirmed the incorporation of 2D-BP into the nanocomposite along with ICP-AES. It was also demonstrated that modifying the initial loading of 2D-BP in the PLGA fibers permitted tunable release rates of phosphate ions over an 8 weeks in vitro study.

Citation

Kamyar, N., Greenhalgh, R., Nascimento, T., Medeiros, E., Matthews, P., Nogueira, L., …Blaker, J. (2018). Exploiting Inherent Instability of 2D Black Phosphorus for Controlled Phosphate Release from Blow-Spun Poly (lactide-co-glycolide) Nanofibers. ACS Applied Nano Material, https://doi.org/10.1021/acsanm.8b00938

Acceptance Date Jul 31, 2018
Publication Date Jul 31, 2018
Journal ACS Applied Nano Materials
Print ISSN 2574-0970
Publisher American Chemical Society
DOI https://doi.org/10.1021/acsanm.8b00938
Keywords black phosphorus, PLGA, solution blow spinning, nanocomposite fibers, phosphate release
Publisher URL http://doi.org/10.1021/acsanm.8b00938