Gas-liquid flow hydrogenation of nitroarenes: Efficient access to a pharmaceutically relevant pyrrolobenzo[1,4]diazepine scaffold
Dimitriou, E; Jones, R; Pritchard, R; Miller, G; O'Brien, M
Using a Tube-in-Tube device based on the amorphous Teflon AF-2400 fluoropolymer, a series of nitroarenes was hydrogenated to afford the corresponding aniline compounds. The system was then applied to the construction of a pyrrolobenzo[1,4]diazapene scaffold through a tandem hydrogenation-condensation-hydrogenation sequence.
|Journal Article Type||Article|
|Acceptance Date||Sep 11, 2018|
|Online Publication Date||Sep 18, 2018|
|Publication Date||Nov 22, 2018|
|Publicly Available Date||May 26, 2023|
|Peer Reviewed||Peer Reviewed|
|Keywords||Gas-liquid flow, Hydrogenation, Pyrrolobenzodiazepine, Reduction, Cyclisation|
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