E Dimitriou
Gas-liquid flow hydrogenation of nitroarenes: Efficient access to a pharmaceutically relevant pyrrolobenzo[1,4]diazepine scaffold
Dimitriou, E; Jones, R; Pritchard, R; Miller, G; O'Brien, M
Authors
Richard Jones r.h.jones@keele.ac.uk
R Pritchard
Gavin Miller g.j.miller@keele.ac.uk
Matthew O'Brien m.obrien@keele.ac.uk
Abstract
Using a Tube-in-Tube device based on the amorphous Teflon AF-2400 fluoropolymer, a series of nitroarenes was hydrogenated to afford the corresponding aniline compounds. The system was then applied to the construction of a pyrrolobenzo[1,4]diazapene scaffold through a tandem hydrogenation-condensation-hydrogenation sequence.
Citation
Dimitriou, E., Jones, R., Pritchard, R., Miller, G., & O'Brien, M. (2018). Gas-liquid flow hydrogenation of nitroarenes: Efficient access to a pharmaceutically relevant pyrrolobenzo[1,4]diazepine scaffold. Tetrahedron, 74(47), 6795-6803. https://doi.org/10.1016/j.tet.2018.09.025
Journal Article Type | Article |
---|---|
Acceptance Date | Sep 11, 2018 |
Online Publication Date | Sep 18, 2018 |
Publication Date | Nov 22, 2018 |
Publicly Available Date | May 26, 2023 |
Journal | Tetrahedron |
Print ISSN | 0040-4020 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 74 |
Issue | 47 |
Pages | 6795-6803 |
DOI | https://doi.org/10.1016/j.tet.2018.09.025 |
Keywords | Gas-liquid flow, Hydrogenation, Pyrrolobenzodiazepine, Reduction, Cyclisation |
Publisher URL | https://doi.org/10.1016/j.tet.2018.09.025 |
Files
Aceepted Manuscript.pdf
(3.7 Mb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by-nc/4.0/
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