Clinical educators' experiences with older adults and the perceived influence on physiotherapy practice and clinical education (2024)
Thesis
Watkins, C. A. Clinical educators' experiences with older adults and the perceived influence on physiotherapy practice and clinical education. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/1018614

Background
Managing older adults within acute care is challenging due to their complex presentation. Experiential learning, via clinical placements and the input of clinical educators, is central to enabling physiotherapy students to manage this pop... Read More about Clinical educators' experiences with older adults and the perceived influence on physiotherapy practice and clinical education.

The prescription and monitoring of conventional synthetic disease-modifying anti-rheumatic drugs: British Society for Rheumatology guideline scope (2024)
Journal Article
Mercer, L., Abhishek, A., Kavirayani, A., Ahmed, A., Davidson, A., Foulkes, A., …Galloway, J. (in press). The prescription and monitoring of conventional synthetic disease-modifying anti-rheumatic drugs: British Society for Rheumatology guideline scope. Rheumatology Advances in Practice, 8(3), Article rkae077. https://doi.org/10.1093/rap/rkae077

Lay Summary: What does this mean for patients? A revised guideline, produced by the British Society for Rheumatology (BSR), will provide up-to-date information about the safe prescribing and monitoring of the effects of non-biologic (or conventional... Read More about The prescription and monitoring of conventional synthetic disease-modifying anti-rheumatic drugs: British Society for Rheumatology guideline scope.

Exploring a Gemcitabine-Glucose Hybrid as a Glycoconjugate Prodrug (2024)
Journal Article
Porter, J., Noble, A. R., Signoret, N., Fascione, M. A., & Miller, G. J. (in press). Exploring a Gemcitabine-Glucose Hybrid as a Glycoconjugate Prodrug. ACS Omega, 9(29), 31703-31713. https://doi.org/10.1021/acsomega.4c02417

Nucleoside analogues are established treatments for cancer and viral infection. Gemcitabine is a commonly employed nucleoside analogue displaying anticancer properties against a range of tumor types but is rapidly inactivated in vivo. Efforts to bols... Read More about Exploring a Gemcitabine-Glucose Hybrid as a Glycoconjugate Prodrug.

Investigating the therapeutic potential of repurposed drugs that target central nervous system and peripheral pathologies in cellular and animal models of spinal muscular atrophy (2024)
Thesis
Çetin, Ö. (2024). Investigating the therapeutic potential of repurposed drugs that target central nervous system and peripheral pathologies in cellular and animal models of spinal muscular atrophy. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/853197

Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by the loss-of-function of the survival motor neuron (SMN) gene resulting in muscle atrophy and weakness. There are currently 3 gene-based therapies (Spinraza®, Zolgensma® and Evrysdi®)... Read More about Investigating the therapeutic potential of repurposed drugs that target central nervous system and peripheral pathologies in cellular and animal models of spinal muscular atrophy.

An investigation of magnetic nanoparticle mediated methods for neuro-regeneration (2024)
Thesis
Nahar, T. S. (2024). An investigation of magnetic nanoparticle mediated methods for neuro-regeneration. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/775525

Conditions such as Parkinsons disease, where specific cell types are affected such as the dopaminergic neurons in the substantia nigra pars compacta, cell transplantation and growth factor therapy could restore function and slow disease progression b... Read More about An investigation of magnetic nanoparticle mediated methods for neuro-regeneration.

Recommended and observed statin use among US adults with and without cancer. (2024)
Journal Article
Kobo, O., Michos, E. D., Roguin, A., Bagur, R., Gulati, M., & Mamas, M. A. (in press). Recommended and observed statin use among US adults with and without cancer. European Journal of Preventive Cardiology, Article zwae057. https://doi.org/10.1093/eurjpc/zwae057

Patients with cancer are at increased cardiovascular risk. We aimed to compare the recommended and observed statin use among individuals with and without cancer. Using three 2-year cycles from the National Health and Nutrition Examination Survey [NHA... Read More about Recommended and observed statin use among US adults with and without cancer..

Investigating the use of marine-derived glycosaminoglycans as mimetics for heparan sulphate in fibroblast growth factor signalling (2023)
Thesis
Chen, S. (2023). Investigating the use of marine-derived glycosaminoglycans as mimetics for heparan sulphate in fibroblast growth factor signalling. (Thesis). Keele University

Fibroblast growth factors (FGFs) are polypeptide growth factors and are potent regulators of cell proliferation, cell differentiation, cell migration and angiogenesis (Ornitz and Itoh, 2001). FGFs can bind with fibroblast growth factor receptors with... Read More about Investigating the use of marine-derived glycosaminoglycans as mimetics for heparan sulphate in fibroblast growth factor signalling.

The potential for compression garments to influence upper limb function in children with unilateral spastic cerebral palsy (2023)
Thesis
Alshehab, M. A. H. A. M. (2023). The potential for compression garments to influence upper limb function in children with unilateral spastic cerebral palsy. (Thesis). Keele University

Cerebral palsy (CP) is an umbrella term that describes a group of people with various motor, sensory and mental dysfunctions caused by permanent damage to the developing brain. Depending on the location and size of the brain damage, signs and symptom... Read More about The potential for compression garments to influence upper limb function in children with unilateral spastic cerebral palsy.

Predicting the potential value of the new discharge medicines service in England (2023)
Journal Article
Thayer, N., Mackridge, A. J., & White, S. (2023). Predicting the potential value of the new discharge medicines service in England. Journal of Pharmaceutical Health Services Research, 14(3), 248-255. https://doi.org/10.1093/jphsr/rmad020

Objectives In 2021, community pharmacies in England were commissioned to support patients post-discharge through the discharge medicines service (DMS). Past studies described the benefit of DMS in avoiding readmissions. This study aimed to estimate t... Read More about Predicting the potential value of the new discharge medicines service in England.

Proteomic Analyses of Autologous Chondrocyte Implantation Plasma Highlight Cartilage Acidic Protein 1 as a Candidate for Preclinical Screening. (2023)
Journal Article
Hulme, C., & Wright, K. (2023). Proteomic Analyses of Autologous Chondrocyte Implantation Plasma Highlight Cartilage Acidic Protein 1 as a Candidate for Preclinical Screening. American Journal of Sports Medicine, 51(6), 1422-1433. https://doi.org/10.1177/03635465231156616

BACKGROUND: Stratification is required to ensure that only patients likely to benefit receive autologous chondrocyte implantation (ACI). It would be advantageous to identify biomarkers to predict ACI outcome that are measurable in blood, avoiding the... Read More about Proteomic Analyses of Autologous Chondrocyte Implantation Plasma Highlight Cartilage Acidic Protein 1 as a Candidate for Preclinical Screening..

Developing in vitro models of traumatic injury for neural tissue engineering applications (2023)
Thesis
Wiseman, J. P. (2023). Developing in vitro models of traumatic injury for neural tissue engineering applications. (Thesis). Keele University

Penetrating traumatic brain injury (pTBI) and spinal cord injury (SCI) cause significant neurological damage and debilitation. The management of these central nervous system (CNS) injuries is largely supportive, with no clinically available regenerat... Read More about Developing in vitro models of traumatic injury for neural tissue engineering applications.

Investigating the therapeutic potential of the glucocorticoid antagonist, mifepristone, for the treatment of spinal muscular atrophy (2023)
Thesis
Sutton, E. R. (2023). Investigating the therapeutic potential of the glucocorticoid antagonist, mifepristone, for the treatment of spinal muscular atrophy. (Thesis). Keele University

Spinal muscular atrophy (SMA) is a neuromuscular disease characterised by loss of alpha motor neurons and muscle atrophy. When untreated, mortality occurs within the first two years of life in the most severe cases. Extensive research has led to thre... Read More about Investigating the therapeutic potential of the glucocorticoid antagonist, mifepristone, for the treatment of spinal muscular atrophy.

Drug Resistance in Medulloblastoma Is Driven by YB-1, ABCB1 and a Seven-Gene Drug Signature. (2023)
Journal Article
Taylor, L., Wade, P. K., Johnson, J. E., Aldighieri, M., Morlando, S., Di Leva, G., …Coyle, B. (2023). Drug Resistance in Medulloblastoma Is Driven by YB-1, ABCB1 and a Seven-Gene Drug Signature. Cancers, 15(4), Article 1086. https://doi.org/10.3390/cancers15041086

Therapy resistance represents an unmet challenge in the treatment of medulloblastoma. Accordingly, the identification of targets that mark drug-resistant cell populations, or drive the proliferation of resistant cells, may improve treatment strategie... Read More about Drug Resistance in Medulloblastoma Is Driven by YB-1, ABCB1 and a Seven-Gene Drug Signature..

Toward a General Protocol for Catalytic Oxidative Transformations Using Electrochemically Generated Hypervalent Iodine Species (2023)
Journal Article
Elsherbini, M., & Moran, W. J. (2023). Toward a General Protocol for Catalytic Oxidative Transformations Using Electrochemically Generated Hypervalent Iodine Species. Journal of Organic Chemistry, 88(3), 1424-1433. https://doi.org/10.1021/acs.joc.2c02309

A simple catalytic electrosynthetic protocol for oxidative transformations mediated by hypervalent iodine reagents has been developed. In this protocol, electricity drives the iodine(I)/iodine(III) catalytic cycle enabling catalysis with in situ gene... Read More about Toward a General Protocol for Catalytic Oxidative Transformations Using Electrochemically Generated Hypervalent Iodine Species.

Hypoxic conditions promote a proliferative, poorly differentiated phenotype in COPD lung tissue progenitor cells in vitro (2023)
Journal Article
Dale, T. P., Santer, M. D., Haris, M., Zuo, W., & Forsyth, N. R. (2023). Hypoxic conditions promote a proliferative, poorly differentiated phenotype in COPD lung tissue progenitor cells in vitro. Experimental Lung Research, 49(1), 12-26. https://doi.org/10.1080/01902148.2022.2158404

PURPOSE: Chronic obstructive pulmonary disease (COPD) patients experience hypoxemia and lung tissue hypoxia, causing vasoconstriction, and at its most severe Cor pulmonale. However, minimal attention has been given to the effects of hypoxia at the ce... Read More about Hypoxic conditions promote a proliferative, poorly differentiated phenotype in COPD lung tissue progenitor cells in vitro.

Latonduine-1-Amino-Hydantoin Hybrid, Triazole-Fused Latonduine Schiff Bases and Their Metal Complexes: Synthesis, X-ray and Electron Diffraction, Molecular Docking Studies and Antiproliferative Activity (2023)
Journal Article
Wittmann, C., Gruene, T., Prado-Roller, A., Aranđelović, S., Reynisson, J., & Arion, V. B. (2023). Latonduine-1-Amino-Hydantoin Hybrid, Triazole-Fused Latonduine Schiff Bases and Their Metal Complexes: Synthesis, X-ray and Electron Diffraction, Molecular Docking Studies and Antiproliferative Activity. Inorganics, 11(1), Article 30. https://doi.org/10.3390/inorganics11010030

A series of latonduine derivatives, namely 11-nitro-indolo[2,3-d]benzazepine-7-(1-amino-hydantoin) (B), triazole-fused indolo[2,3-d]benzazepine-based Schiff bases HL1 and HL2 and metal complexes [M(p-cymene)(HL1)Cl]Cl, where M = Ru (1), Os (2), and [... Read More about Latonduine-1-Amino-Hydantoin Hybrid, Triazole-Fused Latonduine Schiff Bases and Their Metal Complexes: Synthesis, X-ray and Electron Diffraction, Molecular Docking Studies and Antiproliferative Activity.

Genotype-phenotype correlations in human diseases caused by mutations of LINC complex-associated genes: a systematic review and meta-summary (2022)
Journal Article
Fuller, H., & Storey, E. (2022). Genotype-phenotype correlations in human diseases caused by mutations of LINC complex-associated genes: a systematic review and meta-summary. Cells, https://doi.org/10.3390/cells11244065

Mutations in genes encoding proteins associated with the linker of nucleoskel-eton and cytoskeleton (LINC) complex within the nuclear envelope cause dif-ferent diseases with varying phenotypes including skeletal muscle, cardiac, metabolic, or nervous... Read More about Genotype-phenotype correlations in human diseases caused by mutations of LINC complex-associated genes: a systematic review and meta-summary.

Remote magnetic actuation of cell signalling for tissue engineering (2022)
Journal Article
Rotherham, M., Nahar, T., Broomhall, T., Telling, N., & El Haj, A. (2022). Remote magnetic actuation of cell signalling for tissue engineering. Current Opinion in Biomedical Engineering, 24, Article 100410. https://doi.org/10.1016/j.cobme.2022.100410

Magnetic nanoparticles (MNP) are extremely versatile tools in bioengineering and medicine with diverse uses ranging from magnetic resonance contrast agents to drug delivery vehicles. Recently, MNP have been adapted to target and regulate cell signall... Read More about Remote magnetic actuation of cell signalling for tissue engineering.

Directional control of neurite outgrowth: emerging technologies for Parkinson's disease using magnetic nanoparticles and magnetic field gradients. (2022)
Journal Article
Dhillon, K., Aizel, K., Broomhall, T., Secret, E., Goodman, T., Rotherham, M., …Gates, M. (2022). Directional control of neurite outgrowth: emerging technologies for Parkinson's disease using magnetic nanoparticles and magnetic field gradients. Journal of the Royal Society. Interface, 19(196), https://doi.org/10.1098/rsif.2022.0576

A challenge in current stem cell therapies for Parkinson's disease (PD) is controlling neuronal outgrowth from the substantia nigra towards the targeted area where connectivity is required in the striatum. Here we present progress towards controlling... Read More about Directional control of neurite outgrowth: emerging technologies for Parkinson's disease using magnetic nanoparticles and magnetic field gradients..

Heparin: an established anticoagulant drug with therapeutic potential for COVID-19 (2022)
Thesis
McIntosh, O. G. (2022). Heparin: an established anticoagulant drug with therapeutic potential for COVID-19. (Thesis). Keele University

The biologically and medically important heparan sulphate and heparin polysaccharides have been previously shown to mediate viral cell entry for enveloped viruses. Furthermore, heparin and its analogues have been shown to have anti-inflammatory and a... Read More about Heparin: an established anticoagulant drug with therapeutic potential for COVID-19.