Melatonin and health: an umbrella review of health outcomes and biological mechanisms of action

Posadzki, Pawel P.; Bajpai, Ram; Kyaw, Bhone Myint; Roberts, Nicola J.; Brzezinski, Amnon; Christopoulos, George I.; Divakar, Ushashree; Bajpai, Shweta; Soljak, Michael; Dunleavy, Gerard; Jarbrink, Krister; Nang, Ei Ei Khaing; Soh, Chee Kiong; Car, Josip

Abstract

Background
Our aims were to evaluate critically the evidence from systematic reviews as well as narrative reviews of the effects of melatonin (MLT) on health and to identify the potential mechanisms of action involved.

Methods
An umbrella review of the evidence across systematic reviews and narrative reviews of endogenous and exogenous (supplementation) MLT was undertaken. The Oxman checklist for assessing the methodological quality of the included systematic reviews was utilised. The following databases were searched: MEDLINE, EMBASE, Web of Science, CENTRAL, PsycINFO and CINAHL. In addition, reference lists were screened. We included reviews of the effects of MLT on any type of health-related outcome measure.

Results
Altogether, 195 reviews met the inclusion criteria. Most were of low methodological quality (mean -4.5, standard deviation 6.7). Of those, 164 did not pool the data and were synthesised narratively (qualitatively) whereas the remaining 31 used meta-analytic techniques and were synthesised quantitatively. Seven meta-analyses were significant with P values less than 0.001 under the random-effects model. These pertained to sleep latency, pre-operative anxiety, prevention of agitation and risk of breast cancer.

Conclusions
There is an abundance of reviews evaluating the effects of exogenous and endogenous MLT on health. In general, MLT has been shown to be associated with a wide variety of health outcomes in clinically and methodologically heterogeneous populations. Many reviews stressed the need for more high-quality randomised clinical trials to reduce the existing uncertainties.

Citation

Posadzki, P. P., Bajpai, R., Kyaw, B. M., Roberts, N. J., Brzezinski, A., Christopoulos, G. I., …Car, J. (2018). Melatonin and health: an umbrella review of health outcomes and biological mechanisms of action. BMC Medicine, 16, Article 18. https://doi.org/10.1186/s12916-017-1000-8

• Journal Article Type: Article
• Acceptance Date: Dec 20, 2017
• Online Publication Date: Feb 5, 2018
• Publication Date: Feb 5, 2018
• Journal: BMC Medicine
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 16
• Article Number: 18
• DOI: https://doi.org/10.1186/s12916-017-1000-8
• Keywords: Melatonin; Health; Effectiveness; Umbrella review; Systematic reviewsMeta-analyses
• Public URL: https://keele-repository.worktribe.com/output/413010
• Publisher URL: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-017-1000-8#Abs1