Early Clinical Outcomes, Patterns of Failure, and Acute Haematologic Toxicity of Image-Guided Volumetric Modulated Arc Therapy (IG-VMAT) in the Definitive Treatment of Locally Advanced Carcinoma Cervix

Ahmad, Irfan; Chufal, Kundan Singh; Bashir, Irfan; Bhatt, Chandi Prasad; Bajpai, Ram; Sharma, Lalit; Rathour, Sandeep

Abstract

Purpose:To evaluate clinical outcomes and failure patterns in patients with locally advanced cervical cancer (LACC) treated definitively using image-guided volumetric-modulated arc therapy (IG-VMAT).Methods and materials:This retrospective review included 18 consecutively treated patients with LACC. Treatment consisted of IG-VMAT and concurrent chemotherapy followed by intracavitary radiotherapy. The primary end points were overall survival (OS) and disease-free survival (DFS). Acute haematologic toxicity was evaluated using Radiation Therapy Oncology Group (RTOG) criteria.Results:A total of 16 patients were either stage IIB or IIIB and the median follow-up was 30.5 months (interquartile range: 13-36.25 months). The 2-year DFS was 63.3% (95% confidence interval [CI]: 52.8%-72.4%) and 2-year OS was 72.2% (95% CI: 62.1%-80.5%). There were 7 treatment failures, predominantly in-field. Acute haematologic toxicity was low.Conclusions:IG-VMAT is associated with favourable outcomes for patients with LACC.

Citation

Ahmad, I., Chufal, K. S., Bashir, I., Bhatt, C. P., Bajpai, R., Sharma, L., & Rathour, S. (2018). Early Clinical Outcomes, Patterns of Failure, and Acute Haematologic Toxicity of Image-Guided Volumetric Modulated Arc Therapy (IG-VMAT) in the Definitive Treatment of Locally Advanced Carcinoma Cervix. Clinical Medicine Insights: Oncology, 12, 1-10. https://doi.org/10.1177/1179554918783990

• Journal Article Type: Article
• Acceptance Date: May 22, 2018
• Online Publication Date: Jun 27, 2018
• Publication Date: Jun 27, 2018
• Journal: Clinical Medicine Insights : Oncology
• Print ISSN: 1179-5549
• Publisher: SAGE Publications
• Peer Reviewed: Peer Reviewed
• Volume: 12
• Pages: 1-10
• DOI: https://doi.org/10.1177/1179554918783990
• Keywords: Volumetric-modulated arc therapy, image guidance, cervical carcinoma, intensity-modulated radiotherapy, concurrent chemoradiation
• Public URL: https://keele-repository.worktribe.com/output/413012
• Publisher URL: https://doi.org/10.1177/1179554918783990