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Correlative Spectromicroscopy and Tomography for Biomedical Applications involving Electron, Ion, and Soft X-ray Microscopies

Hitchcock, Adam P; Wang, Xiaoyue; Grandfield, Kathryn; Everett, James; Collingwood, Joanna F; Telling, Neil D

Correlative Spectromicroscopy and Tomography for Biomedical Applications involving Electron, Ion, and Soft X-ray Microscopies Thumbnail


Authors

Adam P Hitchcock

Xiaoyue Wang

Kathryn Grandfield

Joanna F Collingwood



Abstract

Many important scientific and technical problems are best addressed using multiple, microscopy-based analytical techniques that combine the strengths of complementary methods. Here, we provide two examples from biomedical challenges: unravelling the attachment zone between dental implants and bone, and uncovering the mechanism of Alzheimer's disease. They combine synchrotron-based scanning transmission X-ray microscopy (STXM) with transmission electron microscopy ((S)TEM), electron tomography (ET), EELS tomography, and/or atom probe tomography (APT). STXM provides X-ray absorption based chemical sensitivity at mesoscale resolution (10–30 nm), which complements higher spatial resolution electron microscopy and APT.

Journal Article Type Article
Acceptance Date Mar 14, 2019
Publication Date Mar 14, 2019
Journal Microscopy Today
Print ISSN 1551-9295
Publisher Cambridge University Press
Peer Reviewed Peer Reviewed
Volume 27
Issue 2
DOI https://doi.org/10.1017/S1551929518001256
Keywords scanning transmission X-ray microscopy; scanning transmission electron microscopy; atom probe tomography; titanium implants; Alzheimer's disease
Publisher URL https://www.cambridge.org/core/journals/microscopy-today/article/correlative-spectromicroscopy-and-tomography-for-biomedical-applications-involving-electron-ion-and-soft-xray-microscopies/1CFAC59353E5E2F0CBF685EE73AAB7C1

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