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Acute myocardial infarction treatments and outcomes in 6.5 million patients with a current or historical diagnosis of cancer in the USA

Bharadwaj, Aditya; Potts, Jessica; Mohamed, Mohamed O; Parwani, Purvi; Swamy, Pooja; Lopez-Mattei, Juan C; Rashid, Muhammad; Kwok, Chun Shing; Fischman, David L; Vassiliou, Vassilios S; Freeman, Philip; Michos, Erin D; Mamas, Mamas A

Acute myocardial infarction treatments and outcomes in 6.5 million patients with a current or historical diagnosis of cancer in the USA Thumbnail


Aditya Bharadwaj

Mohamed O Mohamed

Purvi Parwani

Pooja Swamy

Juan C Lopez-Mattei

Chun Shing Kwok

David L Fischman

Vassilios S Vassiliou

Philip Freeman

Erin D Michos


The aim of this study is to evaluate temporal trends, treatment and clinical outcomes of patients who present with an acute myocardial infarction (AMI) and have a current or historical diagnosis of cancer, according to cancer type and presence of metastases.

Methods and Results:
Data from 6,563,255 patients presenting with an AMI between 2004-2014 from the US National Inpatient Sample (NIS) database were analysed. A total of 5,966,955 had no cancer, 186,604 had current cancer and 409,697 had a historical diagnosis of cancer. Prostate, breast, colon and lung cancer were the four most common types of cancer. Patients with cancer were older with more comorbidities. Differences in invasive treatment were noted, 43.9% received percutaneous coronary intervention (PCI) in patients without cancer whilst only 21.0% of patients with lung cancer received PCI. Lung cancer was associated with the highest in-hospital mortality (odds ratio (OR) 2.71 95% confidence interval (CI) 2.62,2.80), major adverse cardiovascular and cerebrovascular complications (OR 2.38 95% CI 2.31,2.45) and stroke (OR 1.91 95% CI 1.80,2.02), while colon cancer was associated with highest risk of bleeding (OR 2.82 95% CI 2.68,2.98). Irrespective of the type of cancer, presence of metastasis was associated with worse in-hospital outcomes, and historical cancer did not adversely impact on survival (OR 0.90, 95% CI 0.89,0.91).

A concomitant cancer diagnosis is associated with a conservative medical management strategy for AMI, and worse clinical outcomes, compared to patients without cancer. Survival and clinical outcomes in the context of AMI vary significantly according to the type of cancer and metastasis status. The management of this high-risk group is challenging and requires a multidisciplinary and patient-centred approach to improve their outcomes.

Journal Article Type Article
Acceptance Date Nov 13, 2019
Online Publication Date Dec 4, 2019
Publication Date Jun 14, 2020
Publicly Available Date May 26, 2023
Journal European Heart Journal
Print ISSN 0195-668X
Publisher Oxford University Press
Peer Reviewed Peer Reviewed
Volume 41
Issue 23
Pages 2183-2193
Keywords AMI, Cancer, Complications, Mortality, myocardial infarction, acute, cerebrovascular accident, ischemic stroke, cancer, comorbidity, hospital mortality, neoplasm, metastasis, mortality, treatment outcome, lung cancer, colon cancer, cancer diagnosis
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