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Risk of knee osteoarthritis after different types of knee injuries in young adults: a population-based cohort study.

Snoeker, B; Turkiewitz, A; Magnusson, K; Frobell, R; Yu, D; Peat, G; Englund, M

Risk of knee osteoarthritis after different types of knee injuries in young adults: a population-based cohort study. Thumbnail


Authors

B Snoeker

A Turkiewitz

K Magnusson

R Frobell

G Peat

M Englund



Abstract

Objectives
To estimate the risk of clinically-diagnosed knee osteoarthritis (OA) after different types of knee injuries in young adults.

Methods
In a longitudinal cohort study based on population-based healthcare data from Skåne, Sweden, we included all persons aged 25-34 years in 1998-2007 (n=149,288) with and without diagnoses of knee injuries according to ICD-10. We estimated the hazard ratio of
future diagnosed knee OA in injured and uninjured persons using Cox regression, adjusted for potential confounders. We also explored the impact of type of injury (contusion, fracture, dislocation, meniscal tear, cartilage tear/other injury, collateral ligament tear, cruciate ligament tear, and injury to multiple structures) on diagnosed knee OA risk.

Results
We identified 5,247 persons (mean [SD] age 29.4 [2.9] years, 67% men) with a knee injury, and 142,825 persons (mean [SD] age 30.2 [3.0] years, 45% men) without. We found an adjusted hazard ratio of 5.7 (95%CI 5.0-6.6) for diagnosed knee OA in injured compared to uninjured persons during the first 11 years of follow-up and 2.7 (95%CI 2.3 – 3.1) during the following 8 years. The corresponding risk difference (RD) after 19 years of follow-up was 8.1% (95%CI 6.7%-9.4%). Cruciate ligament injury, meniscal tear, and fracture of the tibia plateau/patella were associated with greatest increase in risk (RD of 19.6% (95% CI 13.2%-25.9%), 10.5% (95%CI 6.4%-14.7%), and 6.6% (95%CI 1.1%-12.2%), respectively).

Conclusion
In young adults, knee injury increases the risk of future diagnosed knee OA about 6-fold with highest risks found after cruciate ligament injury, meniscal tear, and intraarticular fracture.

Journal Article Type Article
Acceptance Date Nov 27, 2019
Online Publication Date Jun 1, 2020
Publication Date Dec 11, 2019
Publicly Available Date May 26, 2023
Journal British Journal of Sports Medicine
Print ISSN 0306-3674
Publisher BMJ Publishing Group
Peer Reviewed Peer Reviewed
Volume 54
Issue 12
Pages 725-730
DOI https://doi.org/10.1136/bjsports-2019-100959
Keywords knee injuries; knee ACL; meniscus; fracture; osteoarthritis
Publisher URL http://doi.org/10.1136/bjsports-2019-100959
PMID 31826861

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