Reaching new biocatalytic reactivity using continuous flow reactors

Cosgrove, Sebastian C.

Abstract

The use of flow reactors in biocatalysis has increased significantly in recent years. Chemists have begun to design flow systems that even allow new biocatalytic reactions to take place. This concept article will focus on the design of flow systems that have allowed enzymes to go beyond their limits in batch. The case is made for moving towards fully continuous systems. With flow chemistry increasingly seen as an enabling technology for automated synthesis, and with advancements in AI assisted enzyme design, there is a real possibility to fully automate the development and implementation of a continuous biocatalytic processes. This will lead to significantly improved enzyme processes for synthesis.

Citation

Cosgrove, S. C., & Mattey, A. P. (2022). Reaching new biocatalytic reactivity using continuous flow reactors. Chemistry - A European Journal, 28(13), https://doi.org/10.1002/chem.202103607

• Journal Article Type: Review
• Acceptance Date: Dec 9, 2021
• Online Publication Date: Dec 9, 2021
• Publication Date: Mar 1, 2022
• Journal: Chemistry – A European Journal
• Print ISSN: 0947-6539
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 28
• Issue: 13
• DOI: https://doi.org/10.1002/chem.202103607
• Keywords: Biocatalysis; Biocatalytic Cascades; Continuous Flow Biocatalysis; Immobilisation
• Publisher URL: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202103607