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Cost and effectiveness of one session treatment (OST) for children and young people with specific phobias compared to multi-session cognitive behavioural therapy (CBT): results from a randomised controlled trial

Wang, H-I; Wright, B; Tindall, L; Cooper, C; Biggs, K; Lee, E; Teare, MD; Gega, L; Scott, AJ; Hayward, E; Solaiman, K; Davis, T; McMillan, D; Gilbody, S; Parrott, S

Cost and effectiveness of one session treatment (OST) for children and young people with specific phobias compared to multi-session cognitive behavioural therapy (CBT): results from a randomised controlled trial Thumbnail


Authors

H-I Wang

B Wright

L Tindall

C Cooper

K Biggs

E Lee

MD Teare

L Gega

E Hayward

K Solaiman

T Davis

D McMillan

S Gilbody

S Parrott



Abstract

<jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>In the UK, around 93,000 (0.8%) children and young people (CYP) are experiencing specific phobias that have a substantial impact on daily life. The current gold-standard treatment—multi-session cognitive behavioural therapy (CBT) – is effective at reducing specific phobia severity; however, CBT is time consuming, requires specialist CBT therapists, and is often at great cost and limited availability. A briefer variant of CBT called one session treatment (OST) has been found to offer similar clinical effectiveness for specific phobia as multi-session CBT. The aim of this study was to assess the cost-effectiveness of OST compared to multi-session CBT for CYP with specific phobias through the Alleviating Specific Phobias Experienced by Children Trial (ASPECT), a two-arm, pragmatic, multi-centre, non-inferiority randomised controlled trial.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>CYP aged seven to 16 years with specific phobias were recruited nationally via Health and Social Care pathways, remotely randomised to the intervention group (OST) or the control group (CBT-based therapies) and analysed (<jats:italic>n</jats:italic>?=?267). Resource use based on NHS and personal social services perspective and quality adjusted life years (QALYs) measured by EQ-5D-Y were collected at baseline and at six-month follow-up. Incremental cost-effectiveness ratio (ICER) was calculated, and non-parametric bootstrapping was conducted to capture the uncertainty around the ICER estimates. The results were presented on a cost-effectiveness acceptability curve (CEAC). A set of sensitivity analyses (including taking a societal perspective) were conducted to assess the robustness of the primary findings.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>After adjustment and bootstrapping, on average CYP in the OST group incurred less costs (incremental cost was -£302.96 (95% CI -£598.86 to -£28.61)) and maintained similar improvement in QALYs (QALYs gained 0.002 (95% CI?-?0.004 to 0.008)). The CEAC shows that the probability of OST being cost-effective was over 95% across all the WTP thresholds. Results of a set of sensitivity analyses were consistent with the primary outcomes.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>Compared to CBT, OST produced a reduction in costs and maintained similar improvement in QALYs. Results from both primary and sensitivity analyses suggested that OST was highly likely to be cost saving.</jats:p> </jats:sec><jats:sec> <jats:title>Trial registration</jats:title> <jats:p>ISRCTN19883421 (30/11/2016).</jats:p> </jats:sec>

Acceptance Date Jul 29, 2022
Publication Date Aug 12, 2022
Journal BMC Psychiatry
Publisher Springer Verlag
DOI https://doi.org/10.1186/s12888-022-04192-8
Publisher URL https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-022-04192-8

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