Efficacy and safety of nelarabine in patients with relapsed or refractory T-cell acute lymphoblastic leukemia: a systematic review and meta-analysis

Kathpalia, Meghavi; Mishra, Pinki; Bajpai, Ram; Bhurani, Dinesh; Agarwal, Nidhi

Abstract

Nelarabine is approved for the treatment of relapsed/refractory (R/R) T-cell acute lymphoblastic leukemia (T-ALL) patients who relapse following at least two different chemotherapy regimens. Previous studies have evaluated the efficacy and safety of nelarabine with chemotherapy in the treatment of R/R T-ALL. However, the results are inconsistent. This review aimed to summarize findings on efficacy and safety data in R/R T-ALL patients administered with the drug nelarabine. The present review conducted a comprehensive search of MEDLINE (via PubMed), WHO Clinical Trial Registry, Clinical Trials.gov, and Cochrane Central Register of Controlled Trials until 15 January 2022. Thirteen studies fulfilled the eligibility criteria with a total of 2508 patients. The efficacy of nelarabine was studied in terms of complete remission (CR) and partial remission (PR). Included studies reported overall random-effects pooled prevalence of CR and PR were 37.2 (95% CI: 22.8, 51.5) and 10.2 (95% CI: 4.9, 15.5), respectively. Most common adverse events associated with nelarabine were neutropenia, thrombocytopenia, fatigue, infections, and reversible peripheral neuropathy. Nelarabine is being used as salvage therapy as a bridge to hematopoietic stem cell transplantation and the findings of this meta-analysis indicate that it is an effective and safe treatment to be used in addition to the first-line treatment for R/R T-ALL.

Citation

Kathpalia, M., Mishra, P., Bajpai, R., Bhurani, D., & Agarwal, N. (2022). Efficacy and safety of nelarabine in patients with relapsed or refractory T-cell acute lymphoblastic leukemia: a systematic review and meta-analysis. Annals of Hematology, 101(8), 1655-1666. https://doi.org/10.1007/s00277-022-04880-1

• Journal Article Type: Review
• Acceptance Date: Jun 6, 2022
• Online Publication Date: Jun 21, 2022
• Publication Date: 2022-08
• Journal: ANNALS OF HEMATOLOGY
• Print ISSN: 0939-5555
• Publisher: Springer Verlag
• Volume: 101
• Issue: 8
• Pages: 1655-1666
• DOI: https://doi.org/10.1007/s00277-022-04880-1
• Publisher URL: https://link.springer.com/article/10.1007/s00277-022-04880-1