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Oral anticoagulant prescribing among patients with cancer and atrial fibrillation in England, 2009–2019 (2023)
Journal Article

Background Anticoagulation of patients with atrial fibrillation (AF) and cancer is challenging because of their high risk for stroke and bleeding. Little is known of the variations of oral anticoagulant (OAC) prescribing in patients with AF with and... Read More about Oral anticoagulant prescribing among patients with cancer and atrial fibrillation in England, 2009–2019.

Fourier Transform Infrared microspectroscopy identifies single cancer cells in blood. A feasibility study towards liquid biopsy (2023)
Journal Article

The management of cancer patients has markedly improved with the advent of personalised medicine where treatments are given based on tumour antigen expression amongst other. Within this remit, liquid biopsies will no doubt improve this personalised c... Read More about Fourier Transform Infrared microspectroscopy identifies single cancer cells in blood. A feasibility study towards liquid biopsy.

Aromatase inhibition plus/minus Src inhibitor saracatinib (AZD0530) in advanced breast cancer therapy (ARISTACAT): a randomised phase II study. (2023)
Journal Article

PURPOSE: The development of oestrogen resistance is a major challenge in managing hormone-sensitive metastatic breast cancer. Saracatinib (AZD0530), an oral Src kinase inhibitor, prevents oestrogen resistance in animal models and reduces osteoclast a... Read More about Aromatase inhibition plus/minus Src inhibitor saracatinib (AZD0530) in advanced breast cancer therapy (ARISTACAT): a randomised phase II study..

New insights into the functional role of protein phosphatase 4 regulatory subunit PP4R3A/SMEK1 in the regulation of leukemic cell fate (2023)
Journal Article

The serine/threonine protein phosphatase 4 holoenzyme consists of a PP4 catalytic subunit (PP4c), which interacts with four different regulatory subunits. Previous studies have shown that PP4c acts as a tumour suppressor. Emerging evidence suggests t... Read More about New insights into the functional role of protein phosphatase 4 regulatory subunit PP4R3A/SMEK1 in the regulation of leukemic cell fate.

Tri- modality therapy in advanced esophageal carcinoma: long- term results and insights from a developing world, institutional cohort (2023)
Journal Article

Objective: To evaluate treatment outcomes in patients from a low-middle income country (LMIC) with esophageal carcinoma who underwent esophagectomy after neoadjuvant chemoradiation (NACRT/S). Methods: Between 2010 and 2020, 254 patients (median follo... Read More about Tri- modality therapy in advanced esophageal carcinoma: long- term results and insights from a developing world, institutional cohort.

Predictors for late genitourinary toxicity in men receiving radiotherapy for high-risk prostate cancer using planned and accumulated dose. (2023)
Journal Article

BACKGROUND AND PURPOSE: Significant deviations between bladder dose planned (DP) and dose accumulated (DA) have been reported in patients receiving radiotherapy for prostate cancer. This study aimed to construct multivariate analysis (MVA) models to... Read More about Predictors for late genitourinary toxicity in men receiving radiotherapy for high-risk prostate cancer using planned and accumulated dose..

Cost-effectiveness of 5 fraction and partial breast radiotherapy for early breast cancer in the UK: model-based multi-trial analysis. (2022)
Journal Article

PURPOSE: We estimated the cost-effectiveness of 4 radiotherapy modalities to treat early breast cancer in the UK. In a subgroup of patients eligible for all modalities, we compared whole-breast (WB) and partial breast (PB) radiotherapy delivered in e... Read More about Cost-effectiveness of 5 fraction and partial breast radiotherapy for early breast cancer in the UK: model-based multi-trial analysis..

The Association Between Cancer Diagnosis, Care, and Outcomes in 1 Million Patients Hospitalized for Acute Pulmonary Embolism. (2022)
Journal Article

OBJECTIVES: To evaluate the clinical care provided to cancer patients hospitalized for acute pulmonary embolism (PE), as well as the association between type of cancer, in-hospital care, and clinical outcomes. METHODS: This study examined the in-... Read More about The Association Between Cancer Diagnosis, Care, and Outcomes in 1 Million Patients Hospitalized for Acute Pulmonary Embolism..

Emergency department cardiovascular disease encounters and associated mortality in patients with cancer: A study of 20.6 million records from the USA. (2022)
Journal Article

BACKGROUND: there is limited data on Emergency department (ED) cardiovascular disease (CVD) presentations and outcomes amongst cancer patients. OBJECTIVES: The present study aimed to describe the clinical characteristics, prevalence, and clinical out... Read More about Emergency department cardiovascular disease encounters and associated mortality in patients with cancer: A study of 20.6 million records from the USA..

Percutaneous Coronary Angioplasty in Patients with Cancer: Clinical Challenges and Management Strategies (2022)
Journal Article

The number of cancer survivors in the United States is projected to increase by 31% by 2030. With advances in early screening, diagnosis and therapeutic strategies, a steadily increasing number of patients are surviving cancer. Coronary artery diseas... Read More about Percutaneous Coronary Angioplasty in Patients with Cancer: Clinical Challenges and Management Strategies.

Impact of cancer diagnosis on distribution and trends of cardiovascular hospitalizations in the USA between 2004 to 2017 (2022)
Journal Article

Background and aims There is limited data on temporal trends of cardiovascular hospitalizations and outcomes amongst cancer patients. We describe the distribution, trends of admissions, and in-hospital mortality associated with key cardiovascular di... Read More about Impact of cancer diagnosis on distribution and trends of cardiovascular hospitalizations in the USA between 2004 to 2017.

Diagnostic Models Combining Clinical Information, Ultrasound and Biochemical Markers for Ovarian Cancer: Cochrane Systematic Review and Meta-Analysis. (2022)
Journal Article

BACKGROUND: Ovarian cancer (OC) is a diagnostic challenge, with the majority diagnosed at late stages. Existing systematic reviews of diagnostic models either use inappropriate meta-analytic methods or do not conduct statistical comparisons of models... Read More about Diagnostic Models Combining Clinical Information, Ultrasound and Biochemical Markers for Ovarian Cancer: Cochrane Systematic Review and Meta-Analysis..

The effects of prehabilitation on body composition in patients undergoing multimodal therapy for esophageal cancer. (2022)
Journal Article

Prehabilitation aims to optimize a patient's functional capacity in preparation for surgery. Esophageal cancer patients have a high incidence of sarcopenia and commonly undergo neoadjuvant therapy, which is associated with loss of muscle mass. This s... Read More about The effects of prehabilitation on body composition in patients undergoing multimodal therapy for esophageal cancer..

Musculoskeletal pain and its impact on rates of hospitalisation and mortality in cancer: a linked electronic health record cohort study (MSKCOM) (2022)
Presentation / Conference

Background: Patients with painful musculoskeletal conditions have an increased risk of developing cancer, but less is known about whether this impacts on the longer-term cancer prognosis. This study aims to determine whether patients with painful mus... Read More about Musculoskeletal pain and its impact on rates of hospitalisation and mortality in cancer: a linked electronic health record cohort study (MSKCOM).

Efficacy and safety of nelarabine in patients with relapsed or refractory T-cell acute lymphoblastic leukemia: a systematic review and meta-analysis (2022)
Journal Article

Nelarabine is approved for the treatment of relapsed/refractory (R/R) T-cell acute lymphoblastic leukemia (T-ALL) patients who relapse following at least two different chemotherapy regimens. Previous studies have evaluated the efficacy and safety of... Read More about Efficacy and safety of nelarabine in patients with relapsed or refractory T-cell acute lymphoblastic leukemia: a systematic review and meta-analysis.