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Cancer risk following onset of type 2 diabetes in New Zealanders with impaired glucose tolerance over 25 years: a matched prospective cohort study (2024)
Journal Article
Wang, Z., Yu, D., Osuagwu, U. L., Pickering, K., Baker, J., Cutfield, R., …Simmons, D. (in press). Cancer risk following onset of type 2 diabetes in New Zealanders with impaired glucose tolerance over 25 years: a matched prospective cohort study. BMC Cancer, 24(1), Article 892. https://doi.org/10.1186/s12885-024-12637-4

In people with prediabetes, the link between developing type 2 diabetes (T2D) and cancer risk among those with impaired glucose tolerance (IGT) remains uncertain. We examined this association in IGT individuals from primary care in South and West Auc... Read More about Cancer risk following onset of type 2 diabetes in New Zealanders with impaired glucose tolerance over 25 years: a matched prospective cohort study.

Performance of CHA 2 DS 2 -VASc and HAS-BLED in predicting stroke and bleeding in atrial fibrillation and cancer (2024)
Journal Article
Ajabnoor, A. M., Zghebi, S. S., Parisi, R., Ashcroft, D. M., Faivre-Finn, C., Mamas, M. A., & Kontopantelis, E. (2024). Performance of CHA 2 DS 2 -VASc and HAS-BLED in predicting stroke and bleeding in atrial fibrillation and cancer. European Heart Journal Open, 4(4), Article oeae053. https://doi.org/10.1093/ehjopen/oeae053

Aims: To compare the predictive performance of CHA2DS2-VASc and HAS-BLED scores in atrial fibrillation (AF) patients with and without cancer. Methods and results: Using data from the Clinical Practice Research Datalink in England, we performed a retr... Read More about Performance of CHA 2 DS 2 -VASc and HAS-BLED in predicting stroke and bleeding in atrial fibrillation and cancer.

Recommended and observed statin use among US adults with and without cancer. (2024)
Journal Article
Kobo, O., Michos, E. D., Roguin, A., Bagur, R., Gulati, M., & Mamas, M. A. (in press). Recommended and observed statin use among US adults with and without cancer. European Journal of Preventive Cardiology, Article zwae057. https://doi.org/10.1093/eurjpc/zwae057

Patients with cancer are at increased cardiovascular risk. We aimed to compare the recommended and observed statin use among individuals with and without cancer. Using three 2-year cycles from the National Health and Nutrition Examination Survey [NHA... Read More about Recommended and observed statin use among US adults with and without cancer..

Oral anticoagulant prescribing among patients with cancer and atrial fibrillation in England, 2009–2019 (2023)
Journal Article
Ajabnoor, A. M., Parisi, R., Zghebi, S. S., Ashcroft, D. M., Faivre‐Finn, C., Morris, C., …Kontopantelis, E. (in press). Oral anticoagulant prescribing among patients with cancer and atrial fibrillation in England, 2009–2019. Cancer, https://doi.org/10.1002/cncr.35152

Background
Anticoagulation of patients with atrial fibrillation (AF) and cancer is challenging because of their high risk for stroke and bleeding. Little is known of the variations of oral anticoagulant (OAC) prescribing in patients with AF with and... Read More about Oral anticoagulant prescribing among patients with cancer and atrial fibrillation in England, 2009–2019.

Fourier Transform Infrared microspectroscopy identifies single cancer cells in blood. A feasibility study towards liquid biopsy (2023)
Journal Article
Dowling, L. M., Roach, P., Magnussen, E. A., Kohler, A., Pillai, S., van Pittius, D. G., …Sulé-Suso, J. (in press). Fourier Transform Infrared microspectroscopy identifies single cancer cells in blood. A feasibility study towards liquid biopsy. PLoS ONE, 18(8), Article e0289824. https://doi.org/10.1371/journal.pone.0289824

The management of cancer patients has markedly improved with the advent of personalised medicine where treatments are given based on tumour antigen expression amongst other. Within this remit, liquid biopsies will no doubt improve this personalised c... Read More about Fourier Transform Infrared microspectroscopy identifies single cancer cells in blood. A feasibility study towards liquid biopsy.

Aromatase inhibition plus/minus Src inhibitor saracatinib (AZD0530) in advanced breast cancer therapy (ARISTACAT): a randomised phase II study. (2023)
Journal Article
Oswald, A., Symeonides, S., Wheatley, D., Chan, S., Brunt, A., McAdam, K., …Cameron, D. (2023). Aromatase inhibition plus/minus Src inhibitor saracatinib (AZD0530) in advanced breast cancer therapy (ARISTACAT): a randomised phase II study. Breast Cancer Research and Treatment, 199, https://doi.org/10.1007/s10549-023-06873-8

PURPOSE: The development of oestrogen resistance is a major challenge in managing hormone-sensitive metastatic breast cancer. Saracatinib (AZD0530), an oral Src kinase inhibitor, prevents oestrogen resistance in animal models and reduces osteoclast a... Read More about Aromatase inhibition plus/minus Src inhibitor saracatinib (AZD0530) in advanced breast cancer therapy (ARISTACAT): a randomised phase II study..

New insights into the functional role of protein phosphatase 4 regulatory subunit PP4R3A/SMEK1 in the regulation of leukemic cell fate (2023)
Journal Article
Kavousi, N., Tonge, D. P., & Mourtada-Maarabouni, M. (2023). New insights into the functional role of protein phosphatase 4 regulatory subunit PP4R3A/SMEK1 in the regulation of leukemic cell fate. International Journal of Biological Macromolecules, 233, Article 123467. https://doi.org/10.1016/j.ijbiomac.2023.123467

The serine/threonine protein phosphatase 4 holoenzyme consists of a PP4 catalytic subunit (PP4c), which interacts with four different regulatory subunits. Previous studies have shown that PP4c acts as a tumour suppressor. Emerging evidence suggests t... Read More about New insights into the functional role of protein phosphatase 4 regulatory subunit PP4R3A/SMEK1 in the regulation of leukemic cell fate.

Tri- modality therapy in advanced esophageal carcinoma: long- term results and insights from a developing world, institutional cohort (2023)
Journal Article
Chufal, K. S., Ahmad, I., Bajpai, R., Miller, A. A., Chowdhary, R. L., Makker, J., …Gairola, M. (2023). Tri- modality therapy in advanced esophageal carcinoma: long- term results and insights from a developing world, institutional cohort. British Journal of Radiology, 96(1143), Article ARTN 20220413. https://doi.org/10.1259/bjr.20220413

Objective: To evaluate treatment outcomes in patients from a low-middle income country (LMIC) with esophageal carcinoma who underwent esophagectomy after neoadjuvant chemoradiation (NACRT/S). Methods: Between 2010 and 2020, 254 patients (median follo... Read More about Tri- modality therapy in advanced esophageal carcinoma: long- term results and insights from a developing world, institutional cohort.

Predictors for late genitourinary toxicity in men receiving radiotherapy for high-risk prostate cancer using planned and accumulated dose. (2023)
Journal Article
Kit Loong Tuan, J., Qi Tan, H., Li Kuan Ong, A., Knight, K., Panettieri, V., Dimmock, M., & Wright, C. (2023). Predictors for late genitourinary toxicity in men receiving radiotherapy for high-risk prostate cancer using planned and accumulated dose. https://doi.org/10.1016/j.phro.2023.100421

BACKGROUND AND PURPOSE: Significant deviations between bladder dose planned (DP) and dose accumulated (DA) have been reported in patients receiving radiotherapy for prostate cancer. This study aimed to construct multivariate analysis (MVA) models to... Read More about Predictors for late genitourinary toxicity in men receiving radiotherapy for high-risk prostate cancer using planned and accumulated dose..

Risk-Adapted Target Delineation for Breast Cancer: Controversies and Considerations (2022)
Journal Article
Ahmad, I., Singh Chufal, K., Miller, A. A., Bajpai, R., Chowdhary, R. L., Sharief, M. I., …Gairola, M. (2023). Risk-Adapted Target Delineation for Breast Cancer: Controversies and Considerations. Practical Radiation Oncology, 13(2), E115-E120. https://doi.org/10.1016/j.prro.2022.10.010

The advent of computed tomography–based planning coupled with modern tools for target delineation and hypofractionated treatment schedules has increased efficiency and throughput for patients with breast cancer. While the benefit of adjuvant radiatio... Read More about Risk-Adapted Target Delineation for Breast Cancer: Controversies and Considerations.

Cost-effectiveness of 5 fraction and partial breast radiotherapy for early breast cancer in the UK: model-based multi-trial analysis. (2022)
Journal Article
Glynn, D., Bliss, J., Brunt, A. M., Coles, C. E., Wheatley, D., Haviland, J. S., …Griffin, S. (2022). Cost-effectiveness of 5 fraction and partial breast radiotherapy for early breast cancer in the UK: model-based multi-trial analysis. Breast Cancer Research and Treatment, 197, 405-416. https://doi.org/10.1007/s10549-022-06802-1

PURPOSE: We estimated the cost-effectiveness of 4 radiotherapy modalities to treat early breast cancer in the UK. In a subgroup of patients eligible for all modalities, we compared whole-breast (WB) and partial breast (PB) radiotherapy delivered in e... Read More about Cost-effectiveness of 5 fraction and partial breast radiotherapy for early breast cancer in the UK: model-based multi-trial analysis..

The Association Between Cancer Diagnosis, Care, and Outcomes in 1 Million Patients Hospitalized for Acute Pulmonary Embolism. (2022)
Journal Article
Mamas. (2022). The Association Between Cancer Diagnosis, Care, and Outcomes in 1 Million Patients Hospitalized for Acute Pulmonary Embolism. International Journal of Cardiology, 354-362. https://doi.org/10.1016/j.ijcard.2022.09.049

OBJECTIVES: To evaluate the clinical care provided to cancer patients hospitalized for acute pulmonary embolism (PE), as well as the association between type of cancer, in-hospital care, and clinical outcomes.

METHODS: This study examined the in-... Read More about The Association Between Cancer Diagnosis, Care, and Outcomes in 1 Million Patients Hospitalized for Acute Pulmonary Embolism..

Emergency department cardiovascular disease encounters and associated mortality in patients with cancer: A study of 20.6 million records from the USA. (2022)
Journal Article
Mamas. (2022). Emergency department cardiovascular disease encounters and associated mortality in patients with cancer: A study of 20.6 million records from the USA. International Journal of Cardiology, 210 - 217. https://doi.org/10.1016/j.ijcard.2022.06.053

BACKGROUND: there is limited data on Emergency department (ED) cardiovascular disease (CVD) presentations and outcomes amongst cancer patients. OBJECTIVES: The present study aimed to describe the clinical characteristics, prevalence, and clinical out... Read More about Emergency department cardiovascular disease encounters and associated mortality in patients with cancer: A study of 20.6 million records from the USA..

A genetic model for central chondrosarcoma evolution correlates with patient outcome (2022)
Journal Article
Cross, W., Lyskjær, I., Lesluyes, T., Hargreaves, S., Strobl, A., Davies, C., …Research Consortium, G. E. (2022). A genetic model for central chondrosarcoma evolution correlates with patient outcome. Genome Medicine, 14(99), https://doi.org/10.1186/s13073-022-01084-0

BACKGROUND: Central conventional chondrosarcoma (CS) is the most common subtype of primary malignant bone tumour in adults. Treatment options are usually limited to surgery, and prognosis is challenging. These tumours are characterised by the presenc... Read More about A genetic model for central chondrosarcoma evolution correlates with patient outcome.

Percutaneous Coronary Angioplasty in Patients with Cancer: Clinical Challenges and Management Strategies (2022)
Journal Article
Doolub, G., & Mamas, M. A. (2022). Percutaneous Coronary Angioplasty in Patients with Cancer: Clinical Challenges and Management Strategies. Journal of Personalized Medicine, 12(9), Article 1372. https://doi.org/10.3390/jpm12091372

The number of cancer survivors in the United States is projected to increase by 31% by 2030. With advances in early screening, diagnosis and therapeutic strategies, a steadily increasing number of patients are surviving cancer. Coronary artery diseas... Read More about Percutaneous Coronary Angioplasty in Patients with Cancer: Clinical Challenges and Management Strategies.

Impact of cancer diagnosis on distribution and trends of cardiovascular hospitalizations in the USA between 2004 to 2017 (2022)
Journal Article
Mamas. (2022). Impact of cancer diagnosis on distribution and trends of cardiovascular hospitalizations in the USA between 2004 to 2017. European Heart Journal, 787-797. https://doi.org/10.1093/ehjqcco/qcac045

Background and aims
There is limited data on temporal trends of cardiovascular hospitalizations and outcomes amongst cancer patients. We describe the distribution, trends of admissions, and in-hospital mortality associated with key cardiovascular di... Read More about Impact of cancer diagnosis on distribution and trends of cardiovascular hospitalizations in the USA between 2004 to 2017.

Diagnostic Models Combining Clinical Information, Ultrasound and Biochemical Markers for Ovarian Cancer: Cochrane Systematic Review and Meta-Analysis (2022)
Journal Article
Davenport, C. F., Rai, N., Sharma, P., Deeks, J., Berhane, S., Mallett, S., …Sundar, S. (2022). Diagnostic Models Combining Clinical Information, Ultrasound and Biochemical Markers for Ovarian Cancer: Cochrane Systematic Review and Meta-Analysis. Cancers, 14(15), Article 3621. https://doi.org/10.3390/cancers14153621

Background: Ovarian cancer (OC) is a diagnostic challenge, with the majority diagnosed at late stages. Existing systematic reviews of diagnostic models either use inappropriate meta-analytic methods or do not conduct statistical comparisons of models... Read More about Diagnostic Models Combining Clinical Information, Ultrasound and Biochemical Markers for Ovarian Cancer: Cochrane Systematic Review and Meta-Analysis.

The effects of prehabilitation on body composition in patients undergoing multimodal therapy for esophageal cancer (2022)
Journal Article
Halliday, L., Boshier, P., Doganay, E., Wynter-Blyth, V., Buckley, J., & Moorthy, K. (2022). The effects of prehabilitation on body composition in patients undergoing multimodal therapy for esophageal cancer. Diseases of the Esophagus, https://doi.org/10.1093/dote/doac046

Prehabilitation aims to optimize a patient's functional capacity in preparation for surgery. Esophageal cancer patients have a high incidence of sarcopenia and commonly undergo neoadjuvant therapy, which is associated with loss of muscle mass. This s... Read More about The effects of prehabilitation on body composition in patients undergoing multimodal therapy for esophageal cancer.

Musculoskeletal pain and its impact on rates of hospitalisation and mortality in cancer: a linked electronic health record cohort study (MSKCOM) (2022)
Presentation / Conference
Mason, K., Bailey, J., Heron, N., Marshall, M., Achana, F., Chen, Y., …Jordan, K. (2022, July). Musculoskeletal pain and its impact on rates of hospitalisation and mortality in cancer: a linked electronic health record cohort study (MSKCOM). Paper presented at SAPC ASM 2022 - UCLan 50th Annual Scientific Meeting, University of Central Lancashire, UK

Background: Patients with painful musculoskeletal conditions have an increased risk of developing cancer, but less is known about whether this impacts on the longer-term cancer prognosis. This study aims to determine whether patients with painful mus... Read More about Musculoskeletal pain and its impact on rates of hospitalisation and mortality in cancer: a linked electronic health record cohort study (MSKCOM).