LJ Halliday
The effects of prehabilitation on body composition in patients undergoing multimodal therapy for esophageal cancer
Halliday, LJ; Boshier, PR; Doganay, E; Wynter-Blyth, V; Buckley, J; Moorthy, K
Abstract
Prehabilitation aims to optimize a patient's functional capacity in preparation for surgery. Esophageal cancer patients have a high incidence of sarcopenia and commonly undergo neoadjuvant therapy, which is associated with loss of muscle mass. This study examines the effects of prehabilitation on body composition during neoadjuvant therapy in esophageal cancer patients. In this cohort study, changes in body composition were compared between esophageal cancer patients who participated in prehabilitation during neoadjuvant therapy and controls who did not receive prehabilitation. Assessment of body composition was performed from CT images acquired at the time of diagnosis and after neoadjuvant therapy. Fifty-one prehabilitation patients and 28 control patients were identified. There was a significantly greater fall in skeletal muscle index (SMI) in the control group compared with the prehabilitation patients (? SMI mean difference = -2.2 cm2/m2, 95% CI -4.3 to -0.1, p=0.038). Within the prehabilitation cohort, there was a smaller decline in SMI in patients with =75% adherence to exercise in comparison to those with lower adherence (? SMI mean difference = -3.2, 95% CI -6.0 to -0.5, P =?0.023). A greater decrease in visceral adipose tissue (VAT) was seen with increasing volumes of exercise completed during prehabilitation (P =?0.046). Loss of VAT during neoadjuvant therapy was associated with a lower risk of post-operative complications (P =?0.017). By limiting the fall in SMI and promoting VAT loss, prehabilitation may have multiple beneficial effects in patients with esophageal cancer. Multi-center, randomized studies are needed to further explore these findings.
Citation
Halliday, L., Boshier, P., Doganay, E., Wynter-Blyth, V., Buckley, J., & Moorthy, K. (2022). The effects of prehabilitation on body composition in patients undergoing multimodal therapy for esophageal cancer. Diseases of the Esophagus, https://doi.org/10.1093/dote/doac046
Acceptance Date | Jun 13, 2022 |
---|---|
Publication Date | Jul 7, 2022 |
Publicly Available Date | May 30, 2023 |
Journal | Diseases of the Esophagus |
Print ISSN | 1120-8694 |
Publisher | Oxford University Press |
DOI | https://doi.org/10.1093/dote/doac046 |
Public URL | https://keele-repository.worktribe.com/output/424997 |
Publisher URL | https://academic.oup.com/dote/advance-article/doi/10.1093/dote/doac046/6632930 |
Files
doac046.pdf
(941 Kb)
PDF
Licence
https://creativecommons.org/licenses/by/4.0/
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
Copyright Statement
The Author(s) 2022. Published by Oxford University Press on behalf of International Society for Diseases of the Esophagus. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/ licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
You might also like
Exercise Based Cardiac Rehabilitation: Is a Little Encouragement Enough?
(2022)
Journal Article
Downloadable Citations
About Keele Repository
Administrator e-mail: research.openaccess@keele.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2025
Advanced Search