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Imaging Breast Microcalcifications Using Dark-Field Signal in Propagation-Based Phase-Contrast Tomography.

Imaging Breast Microcalcifications Using Dark-Field Signal in Propagation-Based Phase-Contrast Tomography. Thumbnail


Abstract

Breast microcalcifications are an important primary radiological indicator of breast cancer. However, microcalcification classification and diagnosis may be still challenging for radiologists due to limitations of the standard 2D mammography technique, including spatial and contrast resolution. In this study, we propose an approach to improve the detection of microcalcifications in propagation-based phase-contrast X-ray computed tomography of breast tissues. Five fresh mastectomies containing microcalcifications were scanned at different X-ray energies and radiation doses using synchrotron radiation. Both bright-field (i.e. conventional phase-retrieved images) and dark-field images were extracted from the same data sets using different image processing methods. A quantitative analysis was performed in terms of visibility and contrast-to-noise ratio of microcalcifications. The results show that while the signal-to-noise and the contrast-to-noise ratios are lower, the visibility of the microcalcifications is more than two times higher in the dark-field images compared to the bright-field images. Dark-field images have also provided more accurate information about the size and shape of the microcalcifications.

Citation

Aminzadeh, A., Arhatari, B., Maksimenko, A., Hall, C., Hausermann, D., Peele, A., …Lockie, D. (2022). Imaging Breast Microcalcifications Using Dark-Field Signal in Propagation-Based Phase-Contrast Tomography. IEEE Transactions on Medical Imaging, 2980 - 2990. https://doi.org/10.1109/TMI.2022.3175924

Acceptance Date May 18, 2022
Publication Date Nov 1, 2022
Publicly Available Date Jun 20, 2023
Journal IEEE Transactions on Medical Imaging
Print ISSN 0278-0062
Publisher Institute of Electrical and Electronics Engineers (IEEE)
Pages 2980 - 2990
DOI https://doi.org/10.1109/TMI.2022.3175924
Keywords Breast; X-ray imaging; Computed tomography; Australia; Imaging; Breast cancer; Detectors; dark-field imaging; microcalcifications; propagation-based phase-contrast CT
Publisher URL https://ieeexplore.ieee.org/document/9777732

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