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Predictors for late genitourinary toxicity in men receiving radiotherapy for high-risk prostate cancer using planned and accumulated dose.

Kit Loong Tuan, J; Qi Tan, H; Li Kuan Ong, A; Knight, K; Panettieri, V; Dimmock, M; Wright, C

Predictors for late genitourinary toxicity in men receiving radiotherapy for high-risk prostate cancer using planned and accumulated dose. Thumbnail


Authors

J Kit Loong Tuan

H Qi Tan

A Li Kuan Ong

K Knight

V Panettieri

C Wright



Abstract

BACKGROUND AND PURPOSE: Significant deviations between bladder dose planned (DP) and dose accumulated (DA) have been reported in patients receiving radiotherapy for prostate cancer. This study aimed to construct multivariate analysis (MVA) models to predict the risk of late genitourinary (GU) toxicity with clinical and DP or DA as dose-volume (DV) variables. MATERIALS AND METHODS: Bladder DA obtained from 150 patients were compared with DP. MVA models were built from significant clinical and DV variables (p < 0.05) at univariate analysis. Previously developed dose-based-region-of-interest (DB-ROI) metrics using expanded ring structures from the prostate were included. Goodness-of-fit test and calibration plots were generated to determine model performance. Internal validation was accomplished using Bootstrapping. RESULTS: Intermediate-high DA (V30-65 Gy and DB-ROI-20-50 mm) for bladder increased compared to DP. However, at the very high dose region, DA (D0.003 cc, V75 Gy, and DB-ROI-5-10 mm) were significantly lower. In MVA, single variable models were generated with odds ratio (OR) < 1. DB-ROI-50 mm was predictive of Grade = 1 GU toxicity for DA and DP (DA and DP; OR: 0.96, p: 0.04) and achieved an area under the receiver operating curve (AUC) of > 0.6. Prostate volume (OR: 0.87, p: 0.01) was significant in predicting Grade 2 GU toxicity with a high AUC of 0.81. CONCLUSIONS: Higher DA (V30-65 Gy) received by the bladder were not translated to higher late GU toxicity. DB-ROIs demonstrated higher predictive power than standard DV metrics in associating Grade = 1 toxicity. Smaller prostate volumes have a minor protective effect on late Grade 2 GU toxicity.

Citation

Kit Loong Tuan, J., Qi Tan, H., Li Kuan Ong, A., Knight, K., Panettieri, V., Dimmock, M., & Wright, C. (2023). Predictors for late genitourinary toxicity in men receiving radiotherapy for high-risk prostate cancer using planned and accumulated dose. https://doi.org/10.1016/j.phro.2023.100421

Acceptance Date Jan 25, 2023
Online Publication Date Feb 2, 2023
Publication Date Jan 1, 2023
Journal Physics and Imaging in Radiation Oncology
Print ISSN 2405-6316
Volume 25
Article Number 100421
Pages -
DOI https://doi.org/10.1016/j.phro.2023.100421
Keywords Accumulated dose; Multivariate model; Genitourinary toxicity; Volumetric image-guidance; High-risk prostate cancer
Publisher URL https://www.sciencedirect.com/science/article/pii/S240563162300012X

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