Identification of a Functional Small Noncoding RNA of African Swine Fever Virus

Dunn, Laura E.M.; Ivens, Alasdair; Netherton, Christopher L.; Chapman, David A.G.; Beard, Philippa M.

Abstract

<jats:p>African swine fever (ASF) poses a major threat to pig populations and food security worldwide. The disease is endemic to Africa and Eastern Europe and is rapidly emerging into Asia, where it has led to the deaths of millions of pigs in the last 12?months. The development of safe and effective vaccines to protect pigs against ASF has been hindered by lack of understanding of the complex interactions between ASFV and the host cell. We focused our work on characterizing the interactions between ASFV and sncRNAs. Although comparatively modest changes to host sncRNA abundances were observed upon ASFV infection, we discovered and characterized a novel functional ASFV-encoded sncRNA. The results from this study add important insights into ASFV host-pathogen interactions. This knowledge may be exploited to develop more effective ASFV vaccines that take advantage of the sncRNA system.</jats:p>

Citation

Dunn, L. E., Ivens, A., Netherton, C. L., Chapman, D. A., & Beard, P. M. (2020). Identification of a Functional Small Noncoding RNA of African Swine Fever Virus. Journal of Virology, 94(21), https://doi.org/10.1128/JVI.01515-20

• Journal Article Type: Article
• Acceptance Date: Jul 27, 2020
• Publication Date: Oct 14, 2020
• Journal: Journal of Virology
• Print ISSN: 0022-538X
• Publisher: American Society for Microbiology
• Peer Reviewed: Peer Reviewed
• Volume: 94
• Issue: 21
• DOI: https://doi.org/10.1128/JVI.01515-20
• Publisher URL: https://journals.asm.org/doi/10.1128/JVI.01515-20