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Recreating arterial thrombosis models using tissue-engineered arterial constructs: A method to reduce and replace mice used in platelet research (2023)
Thesis

Intravital microscopy in mice is widely used to study in vivo thrombus formation, however, the relevance of these studies to human physiology is unclear. In this thesis, a 3D tissue-engineered human arterial construct (TEAC) was developed that replic... Read More about Recreating arterial thrombosis models using tissue-engineered arterial constructs: A method to reduce and replace mice used in platelet research.

Training healthcare professionals to be ready for practice in an era of social distancing: A realist evaluation (2023)
Journal Article

Background Programme changes due to the COVID-19 pandemic have impacted variably on preparation for practice of healthcare professional students. Explanations for such variability need exploration. The aim of our study was to understand what clinica... Read More about Training healthcare professionals to be ready for practice in an era of social distancing: A realist evaluation.

Association of frailty status with the causes, characteristics and outcomes of patients with cardiovascular disease using electronic health record data (2023)
Thesis

Introduction Cardiovascular disease (CVD) is the commonest cause of morbidity and mortality worldwide. Frailty is a clinical syndrome of physiological decline, resulting in adverse health outcomes. While the bidirectional relationship between CVD a... Read More about Association of frailty status with the causes, characteristics and outcomes of patients with cardiovascular disease using electronic health record data.

Primary care prescribing of orlistat medication for weight management in adults with type 2 diabetes: an epidemiological study (2023)
Thesis

Introduction The incidence of type 2 Diabetes mellitus (T2DM) is increasing and is a major public health burden. Obesity is one of the main modifiable risk factors for T2DM. However no UK studies have assessed the relationship of orlistat, a medica... Read More about Primary care prescribing of orlistat medication for weight management in adults with type 2 diabetes: an epidemiological study.

Neural immune cell responses to clinically relevant ligands of the niacin receptor (Gpr109a): niacin and monomethyl fumarate (2023)
Thesis

Background: Inflammation is a major driver, and perhaps cause, of neurodegeneration, suggesting neuroimmunomodulation as a therapeutic strategy. Microglia, the primary mediators of neuroinflammation, switch between three activation states [surveillan... Read More about Neural immune cell responses to clinically relevant ligands of the niacin receptor (Gpr109a): niacin and monomethyl fumarate.

The effect of construct configuration on the mechanical stiffness and strength of spinal implants for kyphotic spinal deformity (2023)
Thesis

Spinal deformity involves a wide spectrum of disease, including congenital, developmental, degenerative and traumatic; affecting infant, adolescence and the elderly. Of these, Sheuermann’s kyphosis is a form of developmental long spinal deformity, ch... Read More about The effect of construct configuration on the mechanical stiffness and strength of spinal implants for kyphotic spinal deformity.

The management of varices in acute on chronic liver failure: a systematic review of guidelines and investigation of local practice (2023)
Thesis

Varices are a complication of chronic liver disease and are associated with a high mortality if they haemorrhage. Patients need to be managed using the best available evidence to improve their outcomes. This thesis is formed of two parts: a systemati... Read More about The management of varices in acute on chronic liver failure: a systematic review of guidelines and investigation of local practice.

Mortality across treatment strategies in intermediate-to-high risk pulmonary embolism in the modern era: A meta-analysis of observational studies and RCTs. (2023)
Journal Article

Pulmonary embolism (PE) represents one of the leading causes of death worldwide and mainly treated with medical management, although the utility of more invasive approaches has emerged more recently. This meta-analysis aims to evaluate the 30-day mor... Read More about Mortality across treatment strategies in intermediate-to-high risk pulmonary embolism in the modern era: A meta-analysis of observational studies and RCTs..

Enhanced expression of the human Survival motor neuron 1 gene from a sequence-optimised cDNA transgene in vitro and in vivo (2023)
Journal Article

Spinal muscular atrophy (SMA) is a neuromuscular disease particularly characterised by degeneration of ventral motor neurons. Survival motor neuron (SMN) 1 gene mutations cause SMA, and gene addition strategies to replace the faulty SMN1 copy are a t... Read More about Enhanced expression of the human Survival motor neuron 1 gene from a sequence-optimised cDNA transgene in vitro and in vivo.

Enhanced expression of the human Survival motor neuron 1 gene from a codon-optimised cDNA transgene in vitro and in vivo (2023)
Journal Article

Spinal muscular atrophy (SMA) is a neuromuscular disease particularly characterised by degeneration of ventral motor neurons. Survival motor neuron (SMN) 1 gene mutations cause SMA, and gene addition strategies to replace the faulty SMN1 copy are a t... Read More about Enhanced expression of the human Survival motor neuron 1 gene from a codon-optimised cDNA transgene in vitro and in vivo.

Perception, emotional experiences, and cultural attachments of Ethiopian medical students during human cadaveric dissection (2023)
Journal Article

Human cadaveric dissection has been used in Anatomy teaching for centuries and remains a time-honored and preferred method of instruction. However, the initial exposure to cadaver dissection sometimes evokes emotional reactions in medical students. P... Read More about Perception, emotional experiences, and cultural attachments of Ethiopian medical students during human cadaveric dissection.