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Symptom patterns and life with post-acute COVID-19 in children aged 8-17: a mixed methods studyprotocol.

Faux-Nightingale, Alice; Burton, Claire; Twohig, Helen; Bucknall, Milica; Carroll, Will; Chew-Graham, Carolyn; Dunn, Kathryn; Gilchrist, Francis; Helliwell, Toby; Lawton, Oliver; Lawton, Sarah; Mallen, Christian; Saunders, Benjamin; Van Der Windt, Danielle; Welsh, Victoria

Symptom patterns and life with post-acute COVID-19 in children aged 8-17: a mixed methods studyprotocol. Thumbnail


Authors

Will Carroll

Oliver Lawton



Abstract

Background: While there is a substantial body of knowledge about acute COVID-19, less is known about long-COVID, where symptoms continue beyond 4 weeks.

Aim: To describe longer-term effects of COVID-19 infection in children and young people (CYP) and identify their needs in relation to long-COVID.

Design & setting: This study comprises an observational prospective cohort study and a linked qualitative study, identifying participants aged 8–17 years in the West Midlands of England.

Method: CYP will be invited to complete online questionnaires to monitor incidences and symptoms of COVID-19 over a 12-month period. CYP who have experienced long-term effects of COVID will be invited to interview, and those currently experiencing symptoms will be asked to document their experiences in a diary. Professionals who work with CYP will be invited to explore the impact of long-COVID on the wider experiences of CYP, in a focus group. Descriptive statistics will be used to describe the incidence and rates of resolution of symptoms, and comparisons will be made between exposed and non-exposed groups. Logistic regression models will be used to estimate associations between candidate predictors and the development of long-COVID, and linear regression will be used to estimate associations between candidate predictors. Qualitative data will be analysed thematically using the constant comparison method.

Conclusion: This study will describe features and symptoms of long-COVID and explore the impact of long-COVID within the lives of CYP and their families, to provide better understanding of long-COVID and inform clinical practice.

Journal Article Type Article
Acceptance Date Feb 3, 2023
Online Publication Date Jun 27, 2023
Publication Date 2023-02
Publicly Available Date Jun 20, 2023
Journal BJGP Open
Print ISSN 2398-3795
Publisher Royal College of General Practitioners
Volume 7
Issue 2
Article Number BJGPO20220149
DOI https://doi.org/10.3399/bjgpo.2022.0149
Keywords COVID-19; child health; primary health care; long-COVID; symptom patterns
Publisher URL https://bjgpopen.org/content/early/2023/02/08/BJGPO.2022.0149
PMID 36759021

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