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Sex and country differences in gout: cross-country comparison between Sweden and the UK

Dehlin, M; Muller, S; Mallen, C; Landgren, AJ; Watson, L; Jacobsson, LTH; Roddy, E

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Authors

M Dehlin

AJ Landgren

LTH Jacobsson



Abstract

OBJECTIVE: Compare characteristics, sex differences, and management of gout in Sweden and the UK. METHOD: The results from two separate primary care gout surveys from Sweden and the UK were compared. Participants aged =18 years with gout were sent a questionnaire asking about lifestyle, gout characteristics, uratelowering therapy (ULT), comorbidities, disability, and disease impact. For sex comparison, participants were pooled across countries. RESULTS: In total, 784 (80% male) participants from Sweden and 500 (87% male) from the UK were included. Swedish patients were significantly older at gout onset, mean (SD) age 72 (12) versus 63 (13) years, (p<0.0001), with more comorbidities, and more frequent use of ULT (48% vs 35%, p=0.0005, age-adjusted). Use of alcohol and diuretics was significantly more common among UK patients, who also reported a higher number of gout flares, mean (SD) 2.2 (1.7) versus 1.6 (3.6), (p=0.003) age-adjusted. Females with gout were older at gout onset, mean (SD) age 67 (13) versus 56 (15), (p<0.0001), more often obese, and reported higher use of diuretics. Furthermore, females reported greater impact of gout, more pain and physical limitations, whereas no sex differences were seen in ULT or flares. CONCLUSIONS: In the UK, gout was more frequently associated with modifiable risk factors. People with gout in Sweden were more commonly taking ULT and had lower frequency of gout flares and impact of gout. Females with gout more commonly took diuretics, had higher body mass index, and reported greater physical disability, which should be considered when managing gout in women.

Citation

Dehlin, M., Muller, S., Mallen, C., Landgren, A., Watson, L., Jacobsson, L., & Roddy, E. (2023). Sex and country differences in gout: cross-country comparison between Sweden and the UK. Scandinavian Journal of Rheumatology, 52(6), 673-682. https://doi.org/10.1080/03009742.2023.2177383

Journal Article Type Article
Acceptance Date Feb 3, 2023
Online Publication Date Feb 23, 2023
Publication Date Feb 23, 2023
Publicly Available Date May 30, 2023
Journal Scandinavian Journal of Rheumatology
Print ISSN 0300-9742
Publisher Taylor and Francis
Peer Reviewed Peer Reviewed
Volume 52
Issue 6
Pages 673-682
DOI https://doi.org/10.1080/03009742.2023.2177383
Keywords Immunology, General Medicine, Immunology and Allergy, Rheumatology
Public URL https://keele-repository.worktribe.com/output/425892
Publisher URL https://www.tandfonline.com/doi/full/10.1080/03009742.2023.2177383

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