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Is high sensitivity troponin, taken regardless of a clinical indication, associated with 1 year mortality in critical care patients?

Hinton, Jonathan; Augustine, Maclyn; Gabara, Lavinia; Mariathas, Mark; Allan, Rick; Borca, Florina; Nicholas, Zoe; Gillett, Neil; Kwok, Chun Shing; Cook, Paul; Grocott, Michael PW; Mamas, Mamas; Curzen, Nick


Jonathan Hinton

Maclyn Augustine

Lavinia Gabara

Mark Mariathas

Rick Allan

Florina Borca

Zoe Nicholas

Neil Gillett

Chun Shing Kwok

Paul Cook

Michael PW Grocott

Nick Curzen


The aim of this study was to assess whether high sensitivity troponin (hs-cTnI) is associated with 1 year mortality in critical care (CC). One year mortality data were obtained from NHS Digital for a consecutive cohort of patients admitted to general CC unit (GCCU) and neuroscience CC unit (NCCU) who had hs-cTnI tests performed throughout their CC admission, regardless of whether the test was clinically indicated. Cox proportional hazards were used to estimate the risk of 1-year mortality. A landmark analysis was undertaken to assess whether any relationship at 1 year was driven by mortality within the first 30 days. A total of 1033 consecutive patients were included. At 1 year 254 (24.6%) patients had died. The admission log(10)hs-cTnI concentration in the entire cohort (HR 1.35 (95% CI 1.05–1.75) p = 0.009 with a bootstrap of 1000 samples) was independently associated with 1 year mortality. On landmark analysis the association with 1 year mortality was driven by 30 day mortality. These results indicate that admission hs-cTnI concentration is independently associated with 1 year mortality in CC and this relationship may be driven by differences in mortality at 30 days.

Journal Article Type Article
Acceptance Date Apr 30, 2023
Online Publication Date Mar 30, 2023
Publication Date Mar 30, 2023
Journal Journal of the Intensive Care Society
Print ISSN 1751-1437
Publisher SAGE Publications
Peer Reviewed Peer Reviewed
Volume 24
Issue 4
Pages 392-398
Keywords High sensitivity troponin; myocardial infarction; critical care
Publisher URL