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Prevalence of pulmonary hypertension in myelofibrosis.

Lopez-Mattei, Juan; Verstovsek, Srdan; Fellman, Bryan; Iliescu, Cezar; Bhatti, Karan; Hassan, Saamir A.; Kim, Peter; Gray, Brian A.; Palaskas, Nicolas L.; Grosu, Horiana B.; Mamas, Mamas A.; Faiz, Saadia A.

Authors

Juan Lopez-Mattei

Srdan Verstovsek

Bryan Fellman

Cezar Iliescu

Karan Bhatti

Saamir A. Hassan

Peter Kim

Brian A. Gray

Nicolas L. Palaskas

Horiana B. Grosu

Saadia A. Faiz



Abstract

Pulmonary hypertension (PH) has been described in myelofibrosis (MF), but it is rare and typically found in advanced disease. Although the etiology of PH in MF is unclear, early predictors may be detected by echocardiogram. The goals of our study were to evaluate the prevalence of PH as determined by echocardiography in a cohort of MF patients and to identify clinical risk factors for PH. We performed a retrospective review of MF patients from October 2015 to May 2017 at MD Anderson Cancer Center in the ambulatory clinic, and those with echocardiogram were included. Clinical, echocardiographic, and laboratory data were reviewed. Patients with and without PH were compared using a chi-square or Fisher's exact test, and logistic regression was performed with an outcome variable of PH. There were 143 patients with MF who underwent echocardiogram, and 20 (14%) had echocardiographic findings consistent with PH. Older age, male gender, hypertension, hyperlipidemia, coronary artery disease, dyspnea, hematocrit, brain natriuretic peptide (BNP), and N-terminal prohormone BNP (NT-proBNP) were significantly different between those without PH and those with PH (p?<?0.05). Female gender was protective (OR 0.21, 95% CI 0.049-0.90, p?=?0.035), and NT-proBNP was a significant clinical predictor of PH (OR 1.07, CI 1.02?=?1.12, p?=?0.006). PH in MF is lower than previously reported in our MF cohort, but many patients had cardiac comorbidities. PH due to left-sided heart disease may be underestimated in MF. Evaluation of respiratory symptoms and elevated NT-proBNP should prompt a baseline echocardiogram. Early detection of PH with a multidisciplinary approach may allow treatment of reversible etiologies.

Citation

Lopez-Mattei, J., Verstovsek, S., Fellman, B., Iliescu, C., Bhatti, K., Hassan, S. A., …Faiz, S. A. (2020). Prevalence of pulmonary hypertension in myelofibrosis. Annals of Hematology, 781 - 789. https://doi.org/10.1007/s00277-020-03962-2

Acceptance Date Feb 10, 2020
Publication Date Apr 1, 2020
Journal Annals of Hematology
Print ISSN 0939-5555
Publisher Springer Verlag
Pages 781 - 789
DOI https://doi.org/10.1007/s00277-020-03962-2
Publisher URL https://link.springer.com/article/10.1007/s00277-020-03962-2