509 Association between biologics and major cardiovascular events in adult patients with plaque psoriasis: A cohort study in the British Association of Dermatologists Biologic Interventions Register (BADBIR)

Rungapiromnan, W.; Mason, K.J.; Lunt, M.; McElhone, K.; Rutter, M.K.; Warren, R.B.; Griffiths, C.E.M.; Ashcroft, D.M.

Abstract

The association between biologics and major cardiovascular events (CVEs) in adult patients with plaque psoriasis is unclear. We used prospective cohort data from BADBIR to compared CVE risk associated with different therapies in participants recruited 09/200710/2016. Anti-interleukin-12/23 agent-ustekinumab (UST) was compared with tumour necrosis factor-α inhibitors (TNFi)-etanercept (ETN) and adalimumab (ADA) in a main analysis and UST, ETN or MTX was compared with ADA in a sensitivity analysis. The primary outcome was fatal or non-fatal major CVEs including acute coronary syndrome, unstable angina, myocardial infarction and stroke occurring on therapy or within 90 days after the last dose. Propensity-score weighted Cox proportional hazards regression models estimated hazard ratios (HRs) with 95%confidence interval (CI). 5468 (951 UST and 4517 TNFi) and 7657 (951 UST, 1313 ETN, 2189 MTX and 3204 ADA) biologic naïve patients with plaque psoriasis were included in the main analysis and sensitivity analysis, respectively. No statistically significant differences in the risk of the primary outcome were observed on therapy (adjusted HR for UST vs TNFi:1.17[95% CI 0.492.27]; UST vs ADA:1.06[0.392.89]; ETN vs ADA:0.94[0.32.88]; MTX vs ADA:1.12[0.34.17]) or during drug therapy and within 90 days of the last dose (adjusted HR for UST vs TNFi:0.98[0.432.25]; UST vs ADA:0.87[0.332.3]; ETN vs ADA:0.82[0.282.36]; MTX vs ADA:1.06[0.343.28]). Thus, the risk of major CVEs should not be a key discriminator for choosing biologics for psoriasis treatment.

Citation

Rungapiromnan, W., Mason, K., Lunt, M., McElhone, K., Rutter, M., Warren, R., …Ashcroft, D. (2018). 509 Association between biologics and major cardiovascular events in adult patients with plaque psoriasis: A cohort study in the British Association of Dermatologists Biologic Interventions Register (BADBIR). Journal of Investigative Dermatology, 138(5), S87. https://doi.org/10.1016/j.jid.2018.03.517

• Journal Article Type: Conference Paper
• Online Publication Date: Apr 19, 2018
• Publication Date: 2018-05
• Deposit Date: Jun 20, 2023
• Journal: Journal of Investigative Dermatology
• Print ISSN: 0022-202X
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 138
• Issue: 5
• Pages: S87
• DOI: https://doi.org/10.1016/j.jid.2018.03.517
• Keywords: Cell Biology; Dermatology; Molecular Biology; Biochemistry
• Additional Information: This article is maintained by: Elsevier; Article Title: 509 Association between biologics and major cardiovascular events in adult patients with plaque psoriasis: A cohort study in the British Association of Dermatologists Biologic Interventions Register (BADBIR); Journal Title: Journal of Investigative Dermatology; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.jid.2018.03.517; Content Type: simple-article; Copyright: Copyright © 2018 Published by Elsevier Inc.