P676Percutaneous coronary intervention and clinical outcomes in patients with lymphoma: a 10-year period United States nationwide inpatient sample (NIS) analysis

Borovac, J A; Kwok, C S; Konopleva, M; Kim, P Y; Palaskas, N L; Zaman, A; Butler, R; Lopez-Mattei, J C; Mamas, M A

Abstract

Background
Clinical outcomes and characteristics of patients with lymphoma undergoing percutaneous coronary intervention (PCI) are unknown.

Purpose
To describe clinical characteristics and procedural outcomes in patients that underwent PCI and had a concurrent diagnosis of Hodgkin (HL) or non-Hodgkin (NHL) lymphoma and compare risks of complications and in-hospital mortality in lymphoma subtypes to patients without lymphoma.

Methods
A total of 6,413,175 PCI procedures undertaken in the United States between 2004 and 2014 in the Nationwide Inpatient Sample were included in the analysis. Multivariable regression analysis was performed in order to examine the association between lymphoma diagnosis and clinical outcomes post-PCI including complications and in-hospital mortality.

Results
Patients with lymphoma generally had a significantly higher incidence of post-PCI complications and in-hospital mortality compared to patients without lymphoma (Figure 1). Patients with lymphoma were more likely to experience in-hospital mortality (OR 1.34, 95% CI 1.20–1.49), stroke or transient ischemic attack (TIA) (OR 1.59, 95% CI 1.47–1.73), and any in-hospital complication (OR 1.19, 95% CI 1.14–1.25), following PCI. In the lymphoma subtype-analysis, diagnosis of HL was associated with an increased likelihood of in-hospital death (OR 1.31, 95% CI 1.17–1.48), any in-hospital complication (OR 1.20, 95% CI 1.14–1,26), bleeding complications (OR 1.12 95% CI 1.05–1.19) and vascular complications (OR 1.10 95% CI 1.03–1.17) while these risks were not significantly associated with NHL diagnosis. Finally, both types of lymphoma were associated with an increased likelihood of stroke/TIA following PCI, with this effect being twice greater for HL than NHL diagnosis (OR 1.66, 95% CI 1.52–1.81 and OR 1.33, 95% CI 1.06–1.66, respectively) (Table 1).

Citation

Borovac, J. A., Kwok, C. S., Konopleva, M., Kim, P. Y., Palaskas, N. L., Zaman, A., Butler, R., Lopez-Mattei, J. C., & Mamas, M. A. P676Percutaneous coronary intervention and clinical outcomes in patients with lymphoma: a 10-year period United States nationwide inpatient sample (NIS) analysis. Presented at ESC Congress 2019; 31 August – 4 September 2019, Paris - France

• Presentation Conference Type: Conference Paper (published)
• Conference Name: ESC Congress 2019; 31 August – 4 September 2019
• Online Publication Date: Oct 21, 2019
• Publication Date: Oct 1, 2019
• Deposit Date: Jun 26, 2023
• Journal: European Heart Journal
• Print ISSN: 0195-668X
• Electronic ISSN: 1522-9645
• Publisher: Oxford University Press
• Peer Reviewed: Peer Reviewed
• Volume: 40
• Issue: Supplement_1
• DOI: https://doi.org/10.1093/eurheartj/ehz747.0282
• Keywords: Cardiology and Cardiovascular Medicine; Cardio-Oncology
• Public URL: https://keele-repository.worktribe.com/output/507040