Syndecan-3: A Signaling Conductor in the Musculoskeletal System

Jones, F. K.; Kehoe, O.; Daroszewska, A.; van’t Hof, R. J.; Pisconti, A.

Abstract

Syndecan-3 is a transmembrane proteoglycan, the largest of the four syndecan family members and the most mysterious. To date, the number of published studies involving syndecan-3 is only a small fraction of the number of studies involving the other subfamily member syndecan-1, yet, these few studies on syndecan-3 cover a whole range of biological functions and phenotypes suggesting that syndecan-3 might be the most eclectic and intereting of the four syndecans. In this review, we focus on what is currently known about the role of syndecan-3 in the musculoskeletal system, from development to aging, including regeneration and disease. We also briefly refer to known syndecan-3 functions in other tissues and systems in an attempt to summarize the most up-to-date knowledge while also instilling curiosity about this extraordinary biomolecule and, hopefully, inspiring more research into its biochemistry and biological functions.

• Online Publication Date: Jun 8, 2021
• Publication Date: 2021
• Deposit Date: Jun 28, 2023
• Publisher: Springer
• Pages: 153-177
• Series Title: Biology of Extracellular Matrix
• Series ISSN: 0887-3224
• Book Title: Proteoglycans in Stem Cells
• Chapter Number: 6
• ISBN: 9783030734527; 9783030734534
• DOI: https://doi.org/10.1007/978-3-030-73453-4_7
• Keywords: Syndecan-3; Muscle; Bone; Cartilage; Proteoglycans; Development; Regeneration; Stem cells
• Additional Information: First Online: 8 June 2021