Syndecan-3: A Signaling Conductor in the Musculoskeletal System

Jones, F. K.; Kehoe, O.; Daroszewska, A.; van’t Hof, R. J.; Pisconti, A.

Abstract

Syndecan-3 is a transmembrane proteoglycan, the largest of the four syndecan family members and the most mysterious. To date, the number of published studies involving syndecan-3 is only a small fraction of the number of studies involving the other subfamily member syndecan-1, yet, these few studies on syndecan-3 cover a whole range of biological functions and phenotypes suggesting that syndecan-3 might be the most eclectic and intereting of the four syndecans. In this review, we focus on what is currently known about the role of syndecan-3 in the musculoskeletal system, from development to aging, including regeneration and disease. We also briefly refer to known syndecan-3 functions in other tissues and systems in an attempt to summarize the most up-to-date knowledge while also instilling curiosity about this extraordinary biomolecule and, hopefully, inspiring more research into its biochemistry and biological functions.

Citation

Jones, F. K., Kehoe, O., Daroszewska, A., van’t Hof, R. J., & Pisconti, A. (2021). Syndecan-3: A Signaling Conductor in the Musculoskeletal System. In Proteoglycans in Stem Cells (153-177). Springer. https://doi.org/10.1007/978-3-030-73453-4_7

• Online Publication Date: Jun 8, 2021
• Publication Date: 2021
• Deposit Date: Jun 28, 2023
• Publisher: Springer
• Pages: 153-177
• Series Title: Biology of Extracellular Matrix
• Series ISSN: 0887-3224
• Book Title: Proteoglycans in Stem Cells
• Chapter Number: 6
• ISBN: 9783030734527; 9783030734534
• DOI: https://doi.org/10.1007/978-3-030-73453-4_7
• Keywords: Syndecan-3; Muscle; Bone; Cartilage; Proteoglycans; Development; Regeneration; Stem cells
• Additional Information: First Online: 8 June 2021