Socioeconomic disparities in the management and outcomes of acute myocardial infarction

Weight, Nicholas; Moledina, Saadiq; Volgman, Annabelle Santos; Bagur, Rodrigo; Wijeysundera, Harindra C; Sun, Louise Y; Chadi Alraies, M; Rashid, Muhammad; Kontopantelis, Evangelos; Mamas, Mamas A

Abstract

Background: Patients from lower socioeconomic status areas have poorer outcomes following acute myocardial infarction (AMI); however, how ethnicity modifies such socioeconomic disparities is unclear.

Methods: Using the UK Myocardial Ischaemia National Audit Project (MINAP) registry, we divided 370 064 patients with AMI into quintiles based on Index of Multiple Deprivation (IMD) score, comprising seven domains including income, health, employment and education. We compared white and ‘ethnic-minority’ patients, comprising Black, Asian and mixed ethnicity patients (as recorded in MINAP); further analyses compared the constituents of the ethnic-minority group. Logistic regression models examined the role of the IMD, ethnicity and their interaction on the odds of in-hospital mortality.

Results: More patients from the most deprived quintile (Q5) were from ethnic-minority backgrounds (Q5; 15% vs Q1; 4%). In-hospital mortality (OR 1.10, 95% CI 1.01 to 1.19, p=0.025) and major adverse cardiovascular event (MACE) (OR 1.07, 95% CI 1.00 to 1.15, p=0.048) were more likely in Q5, and MACE was more likely in ethnic-minority patients (OR 1.40, 95% CI 1.00 to 1.95, p=0.048) versus white (OR 1.05, 95% CI 0.98 to 1.13, p=0.027) in Q5. In subgroup analyses, Black patients had the highest in-hospital mortality within the most affluent quintile (Q1) (Black: 0.079, 95% CI 0.046 to 0.112, p<0.001; White: 0.062, 95% CI 0.059 to 0.066, p<0.001), but not in Q5 (Black: 0.065, 95% CI 0.054 to 0.077, p<0.001; White: 0.065, 95% CI 0.061 to 0.069, p<0.001).

Conclusion: Patients with a higher deprivation score were more often from an ethnic-minority background, more likely to suffer in-hospital mortality or MACE when compared with the most affluent quintile, and this relationship was stronger in ethnic minorities compared with White patients.

Citation

Weight, N., Moledina, S., Volgman, A. S., Bagur, R., Wijeysundera, H. C., Sun, L. Y., Chadi Alraies, M., Rashid, M., Kontopantelis, E., & Mamas, M. A. (2023). Socioeconomic disparities in the management and outcomes of acute myocardial infarction. Heart, heartjnl-2023-322601. https://doi.org/10.1136/heartjnl-2023-322601

• Journal Article Type: Article
• Acceptance Date: Jul 21, 2023
• Online Publication Date: Aug 9, 2023
• Publication Date: Aug 1, 2023
• Deposit Date: Aug 22, 2023
• Publicly Available Date: Aug 22, 2023
• Journal: Heart
• Print ISSN: 1355-6037
• Electronic ISSN: 1468-201X
• Publisher: BMJ Publishing Group
• Peer Reviewed: Peer Reviewed
• Pages: heartjnl-2023-322601
• DOI: https://doi.org/10.1136/heartjnl-2023-322601
• Keywords: Percutaneous Coronary Intervention, Epidemiology, Cardiac Catheterisation, Coronary Artery Disease, Acute myocardial infarction
• Public URL: https://keele-repository.worktribe.com/output/543370
• Publisher URL: https://heart.bmj.com/content/early/2023/08/09/heartjnl-2023-322601