Effect of Conventional Lifestyle Interventions on Type 2 Diabetes Incidence by Glucose-Defined Prediabetes Phenotype: An Individual-Participant Data Meta-analysis of Randomized Controlled Trials.

Sathish, Thirunavukkarasu; Khunti, Kamlesh; Narayan, K M Venkat; Mohan, Viswanathan; Davies, Melanie J; Yates, Thomas; Oldenburg, Brian; Thankappan, Kavumpurathu R; Tapp, Robyn J; Bajpai, Ram; Anjana, Ranjit Mohan; Weber, Mary B; Ali, Mohammed K; Shaw, Jonathan E

Abstract

To examine whether the effect of conventional lifestyle interventions on type 2 diabetes incidence differs by glucose-defined prediabetes phenotype. We searched multiple databases until 1 April 2023 for randomized controlled trials that recruited people with isolated impaired fasting glucose (i-IFG), isolated impaired glucose tolerance (i-IGT), and impaired fasting glucose plus impaired glucose tolerance (IFG+IGT). Individual-participant data were pooled from relevant trials and analyzed through random-effects models with use of the within-trial interactions approach. Four trials with 2,794 participants (mean age 53.0 years, 60.7% men) were included: 1,240 (44.4%), 796 (28.5%), and 758 (27.1%) had i-IFG, i-IGT, and IFG+IGT, respectively. After a median of 2.5 years, the pooled hazard ratio for diabetes incidence in i-IFG was 0.97 (95% CI 0.66, 1.44), i-IGT 0.65 (0.44, 0.96), and IFG+IGT 0.51 (0.38, 0.68; Pinteraction = 0.01). Conventional lifestyle interventions reduced diabetes incidence in people with IGT (with or without IFG) but not in those with i-IFG. [Abstract copyright: © 2023 by the American Diabetes Association.]

Citation

Sathish, T., Khunti, K., Narayan, K. M. V., Mohan, V., Davies, M. J., Yates, T., Oldenburg, B., Thankappan, K. R., Tapp, R. J., Bajpai, R., Anjana, R. M., Weber, M. B., Ali, M. K., & Shaw, J. E. (in press). Effect of Conventional Lifestyle Interventions on Type 2 Diabetes Incidence by Glucose-Defined Prediabetes Phenotype: An Individual-Participant Data Meta-analysis of Randomized Controlled Trials. Diabetes Care, 46(11), 1903–1907. https://doi.org/10.2337/dc23-0696

• Journal Article Type: Review
• Acceptance Date: Jul 11, 2023
• Online Publication Date: Aug 31, 2023
• Deposit Date: Sep 7, 2023
• Journal: Diabetes Care
• Print ISSN: 0149-5992
• Electronic ISSN: 1935-5548
• Publisher: American Diabetes Association
• Peer Reviewed: Peer Reviewed
• Volume: 46
• Issue: 11
• Pages: 1903–1907
• DOI: https://doi.org/10.2337/dc23-0696
• Public URL: https://keele-repository.worktribe.com/output/563510
• Publisher URL: https://diabetesjournals.org/care/article-abstract/doi/10.2337/dc23-0696/153568/Effect-of-Conventional-Lifestyle-Interventions-on?redirectedFrom=fulltext
• PMID: 37650824