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Influence of polymorphisms at glutathione-S-transferase gene loci on allelic losses in head and neck squamous cell carcinomas,Einfluss yon genpolymorphismen in den entgiftenden enzymen der glutathion-S-transferasen auf die chromosomale stabilitat yon plattenepithelkarzinomen im kopf-hals-bereich

Matthias, C.; Bockmühl, U.; Jahnke, V.; Petersen, I.; Dietel, M.; Fryer, A.; Strange, R.C.

Authors

C. Matthias

U. Bockmühl

V. Jahnke

I. Petersen

M. Dietel

R.C. Strange



Contributors

C. Matthias
Other

U. Bockmühl
Other

V. Jahnke
Other

I. Petersen
Other

M. Dietel
Other

A. Fryer
Other

R.C. Strange
Other

Abstract

Background: While cigarette smoking and chronic alcohol consumption are the major risk factors for the development of head and neck cancer, it is assumed that genetic factors contribute to risk. Material and methods: We examined genotype frequencies from leukocyte DNA of 269 laryngeal cancer patients, 123 pharyngeal cancer patients and 216 controls. Polymorphisms at different glutathione-S-transferase (GST) gene loci were investigated. Losses of heterozygosity (LOH) at 12 different chromosomal gene loci were determined in 37 of the study patients by comparing blood and tumor cell DNA. The relationship between high risk genotypes and the occurrence of LOH was investigated. Results: Glutathione-S-transferase high risk genotypes were identified at the first and third genes of the M family (GSTM1, GSTM3) and the first gene of the P family (GSTP1). These high risk genotypes are seen to have a statistically significant influence on the occurrence of LOH in the tumor tissue. Conclusion: There is evidence that the polymorphisms studied play a role in the carcinogenic process by influencing the chromosomal fragility which may lead to the inactivation of tumor suppressor genes or the activation of oncogenes.

Citation

Matthias, C., Bockmühl, U., Jahnke, V., Petersen, I., Dietel, M., Fryer, A., & Strange, R. (1998). Influence of polymorphisms at glutathione-S-transferase gene loci on allelic losses in head and neck squamous cell carcinomas,Einfluss yon genpolymorphismen in den entgiftenden enzymen der glutathion-S-transferasen auf die chromosomale stabilitat yon plattenepithelkarzinomen im kopf-hals-bereich. Laryngo-Rhino-Otologie, 77(4), 201-206. https://doi.org/10.1055/s-2007-996961

Journal Article Type Article
Online Publication Date Feb 29, 2008
Publication Date 1998
Deposit Date Apr 19, 2024
Journal Laryngo-Rhino-Otologie
Print ISSN 0935-8943
Publisher Thieme Gruppe
Peer Reviewed Peer Reviewed
Volume 77
Issue 4
Pages 201-206
DOI https://doi.org/10.1055/s-2007-996961


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