Studies on the expression of Cu,Zn superoxide dismutase in human tissues during development.

Strange, Richard C.; Cotton, William; Fryer, Anthony A.; Drew, Roger; Bradwell, Arthur R.; Marshall, Tom; Collins, Mike F.; Bell, Jeanne; Hume, Robert

Abstract

The developmental expression of Cu,Zn superoxide dismutase in human lung and erythrocytes has been studied using activity measurements, immunoblotting and immunohistochemistry. Enzyme activity in erythrocytes increased significantly during gestation but no developmental trend was seen in lung. Immunoblotting identified a single enzyme form that was present in a variety of tissues and immunohistochemistry showed the enzyme to have widespread distribution in lung tissue. These data indicate that Cu,Zn superoxide dismutase is consistently expressed during human development and that, unlike in other species. no late-fetal surge in expression occurs.

Citation

Strange, R. C., Cotton, W., Fryer, A. A., Drew, R., Bradwell, A. R., Marshall, T., …Hume, R. (1988). Studies on the expression of Cu,Zn superoxide dismutase in human tissues during development. BBA - Biochimica et Biophysica Acta, https://doi.org/10.1016/0304-4165%2888%2990174-2

• Journal Article Type: Article
• Online Publication Date: Dec 11, 2002
• Publication Date: 1988-02
• Deposit Date: Feb 8, 2024
• Journal: Biochimica et Biophysica Acta
• Print ISSN: 0006-3002
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1016/0304-4165%2888%2990174-2
• Publisher URL: https://www.sciencedirect.com/science/article/abs/pii/0304416588901742?via%3Dihub
• PMID: 3277672