The development of glutathione S-transferase and glutathione peroxidase activities in human lung.

Fryer, Anthony A.; Hume, Robert; Strange, Richard C.

Abstract

The development of glutathione S-transferase and glutathione peroxidase activities has been studied in human lung cytosols. Whilst no clear change in glutathione peroxidase activity was identified, expression of the acidic glutathione S-transferase isoenzyme decreased markedly after 15 weeks of gestation so that at birth the level of activity of this isoenzyme was only about 20% of that in samples obtained during the first trimester. Basic glutathione S-transferase isoenzymes were weakly expressed during development and usually comprised less than 10% of cytosolic activity. Ion-exchange studies identified several basic isoenzymes that may correspond to the α, β, γ, δ and ϵ set previously identified in liver. Weak expression of apparently near-neutral isoenzymes was also detected; they were detected in only a few cytosols.

Citation

Fryer, A. A., Hume, R., & Strange, R. C. (1986). The development of glutathione S-transferase and glutathione peroxidase activities in human lung. BBA - Biochimica et Biophysica Acta, 883(3), 448-453. https://doi.org/10.1016/0304-4165%2886%2990283-7

• Journal Article Type: Article
• Online Publication Date: Jan 7, 2003
• Publication Date: 1986-10
• Deposit Date: Jan 26, 2024
• Journal: Biochimica et Biophysica Acta
• Print ISSN: 0006-3002
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 883
• Issue: 3
• Pages: 448-453
• DOI: https://doi.org/10.1016/0304-4165%2886%2990283-7
• PMID: 3756211