Characteristics of ‘super responders’ and ‘super nonresponders’ to first biologic monotherapy for psoriasis: a nested case–control study

Mason, Kayleigh J; Alabas, Oras A; Dand, Nick; Warren, Richard B; Reynolds, Nick J; Barker, Jonathan N W N; Yiu, Zenas Z N; Smith, Catherine H; Griffiths, Christopher E M; Barker, Jonathan; Morrison, Simon; Bewley, Anthony; Evans, Ian; Griffiths, Christopher; Ahmed, Shehnaz; Kirby, Brian; Kleyn, Elise; Laws, Philip; Hampton, Philip; Alabas, Oras; McElhone, Kathleen; Yiu, Zenas; Mackenzie, Teena; McPherson, Tess; Murphy, Ruth; Ormerod, Anthony; Walton, Shernaz; Reynolds, Nick; Smith, Catherine; Shipman, Alexa; Ye, Christina; Hughes, Olivia; Warren, Richard; Browne, Fiona; Lawson, Linda; Owen, Caroline; Pearson, Eleanor; Richards, Josh; Warren, Richard

Abstract

It is unknown why some psoriasis patients experience long-term effectiveness with their first biologic monotherapy. Our aim was to compare the baseline demographic, disease, genotypic, clinical and lifestyle characteristics of patients with psoriasis registered to BADBIR and the aligned BSTOP study and designated as super responders (SRs), defined as patients on their first biologic with more than 5 years continuous biologic monotherapy or SNRs, defined as patients on their first biologic who had discontinued at least two biologics in their first year of treatment, to biologic therapy. Female sex, shorter study follow-up, higher DLQI, high frequency of adalimumab, less frequency of ustekinumab at registration, and higher number of comorbidities were associated with SNRs compared with SRs.

Citation

Mason, K. J., Alabas, O. A., Dand, N., Warren, R. B., Reynolds, N. J., Barker, J. N. W. N., Yiu, Z. Z. N., Smith, C. H., Griffiths, C. E. M., Barker, J., Morrison, S., Bewley, A., Evans, I., Griffiths, C., Ahmed, S., Kirby, B., Kleyn, E., Laws, P., Hampton, P., Alabas, O., …Warren, R. (2024). Characteristics of ‘super responders’ and ‘super nonresponders’ to first biologic monotherapy for psoriasis: a nested case–control study. British Journal of Dermatology, 190(3), 441–444. https://doi.org/10.1093/bjd/ljad446

• Journal Article Type: Article
• Acceptance Date: Nov 9, 2023
• Online Publication Date: Nov 11, 2023
• Publication Date: 2024-03
• Deposit Date: Nov 27, 2023
• Journal: British Journal of Dermatology
• Print ISSN: 0007-0963
• Electronic ISSN: 1365-2133
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 190
• Issue: 3
• Pages: 441–444
• DOI: https://doi.org/10.1093/bjd/ljad446
• Keywords: Dermatology
• Public URL: https://keele-repository.worktribe.com/output/646154